{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:43:06Z","timestamp":1768981386352,"version":"3.49.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Antibiotic-induced bacteriolysis exacerbates inflammation and brain damage in bacterial meningitis. Here the quality and temporal kinetics of cerebrospinal fluid (CSF) inflammation were assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone. Daptomycin led to lower CSF concentrations of interleukin 1\u03b2 (IL-1\u03b2), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1\u03b1) (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). In experimental pneumococcal meningitis, daptomycin treatment resulted in more rapid bacterial killing, lower CSF inflammation, and less brain damage than ceftriaxone treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.00812-09","type":"journal-article","created":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T02:59:16Z","timestamp":1263265156000},"page":"1323-1326","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":56,"title":["Attenuation of Cerebrospinal Fluid Inflammation by the Nonbacteriolytic Antibiotic Daptomycin versus That by Ceftriaxone in Experimental Pneumococcal Meningitis"],"prefix":"10.1128","volume":"54","author":[{"given":"Denis","family":"Grandgirard","sequence":"first","affiliation":[{"name":"Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Oberson","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Bu\u0308hlmann","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahel","family":"Ga\u0308umann","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Neuroinfectiology, Institute for Infectious Diseases, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.02.031"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10142"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3928-3933.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00952-08"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.01930.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2001.tb00410.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01014-06"},{"key":"e_1_3_2_9_2","first-page":"588","volume":"47","year":"2008","unstructured":"Lee, D. H., B. Palermo, and M. Chowdhury. 2008. Successful treatment of methicillin-resistant staphylococcus aureus meningitis with daptomycin. Clin. Infect. Dis.47:588-590.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_10_2","first-page":"4","volume":"4","year":"2003","unstructured":"Leib, S. L., C. Heimgartner, Y. D. Bifrare, J. M. Loeffler, and M. G. T\u00e4uber. 2003. Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats. Pediatr. Res.4:4.","journal-title":"Pediatr. Res."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/317921"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200206000-00007"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01949-05"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-50"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2005.01.001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1714-1718.2003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710023371404"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a036c0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01000-06"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000108106"},{"key":"e_1_3_2_21_2","first-page":"CD004405","volume":"2007","year":"2007","unstructured":"van de Beek, D., J. de Gans, P. McIntyre, and K. Prasad. 2007. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst. Rev.2007:CD004405.","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00812-09","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00812-09","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:25:14Z","timestamp":1645475114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00812-09"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1128\/AAC.00812-09"],"URL":"https:\/\/doi.org\/10.1128\/aac.00812-09","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"2009-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}