{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:00:21Z","timestamp":1793199621064,"version":"4.5.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21-AI114961"],"award-info":[{"award-number":["R21-AI114961"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K24-AI114818"],"award-info":[{"award-number":["K24-AI114818"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01-AI093749"],"award-info":[{"award-number":["R01-AI093749"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21\/R33 AI121519"],"award-info":[{"award-number":["R21\/R33 AI121519"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["130871250417\/906-2015"],"award-info":[{"award-number":["130871250417\/906-2015"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            is an important pathogen causing a spectrum of diseases ranging from mild skin and soft tissue infections to life-threatening conditions. Bloodstream infections are particularly important, and the treatment approach is complicated by the presence of methicillin-resistant\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            (MRSA) isolates. The emergence of new genetic lineages of MRSA has occurred in Latin America (LA) with the rise and dissemination of the community-associated USA300 Latin American variant (USA300-LV). Here, we prospectively characterized bloodstream MRSA recovered from selected hospitals in 9 Latin American countries. All isolates were typed by pulsed-field gel electrophoresis (PFGE) and subjected to antibiotic susceptibility testing. Whole-genome sequencing was performed on 96 MRSA representatives. MRSA represented 45% of all (1,185\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            ) isolates. The majority of MRSA isolates belonged to clonal cluster (CC) 5. In Colombia and Ecuador, most isolates (\u226572%) belonged to the USA300-LV lineage (CC8). Phylogenetic reconstructions indicated that MRSA isolates from participating hospitals belonged to three major clades. Clade A grouped isolates with sequence type 5 (ST5), ST105, and ST1011 (mostly staphylococcal chromosomal cassette\n            <jats:italic>mec<\/jats:italic>\n            [SCC\n            <jats:italic>mec<\/jats:italic>\n            ] I and II). Clade B included ST8, ST88, ST97, and ST72 strains (SCC\n            <jats:italic>mec<\/jats:italic>\n            IV, subtypes a, b, and c\/E), and clade C grouped mostly Argentinian MRSA belonging to ST30. In summary, CC5 MRSA was prevalent in bloodstream infections in LA with the exception of Colombia and Ecuador, where USA300-LV is now the dominant lineage. Clonal replacement appears to be a common phenomenon, and continuous surveillance is crucial to identify changes in the molecular epidemiology of MRSA.\n          <\/jats:p>","DOI":"10.1128\/aac.00816-17","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:35:13Z","timestamp":1501547713000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":100,"title":["A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries"],"prefix":"10.1128","volume":"61","author":[{"given":"Cesar A.","family":"Arias","sequence":"first","affiliation":[{"name":"Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, University of Texas McGovern Medical School at Houston, Houston, Texas, USA"},{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinnethe","family":"Reyes","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Paola","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Rincon","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Diaz","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Panesso","sequence":"additional","affiliation":[{"name":"Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, University of Texas McGovern Medical School at Houston, Houston, Texas, USA"},{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Ibarra","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Rios","sequence":"additional","affiliation":[{"name":"Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Munita","sequence":"additional","affiliation":[{"name":"Grupo de Genomica Microbiana, Instituto de Ciencias e Innovacion en Medicina, Clinica Alemana, Universidad del Desarrollo, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro J.","family":"Salles","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Santa Casa de Sao Paulo School of Medicine, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Alvarez-Moreno","sequence":"additional","affiliation":[{"name":"Unidad Infectologia, Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Clinica Universitaria Colombia, Colsanitas, Bogota, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Labarca","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralith","family":"Garcia","sequence":"additional","affiliation":[{"name":"Hospital Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Luna","sequence":"additional","affiliation":[{"name":"Pulmonary 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