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To support further development of this compound into a patient-friendly oral or topical formulation for the treatment of CL, we investigated the free drug exposure at the dermal site of infection and subsequent elimination of the causative\n            <jats:italic>Leishmania<\/jats:italic>\n            pathogen.\n          <\/jats:p>","DOI":"10.1128\/aac.00829-19","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T10:43:10Z","timestamp":1561545790000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis"],"prefix":"10.1128","volume":"63","author":[{"given":"Gert-Jan","family":"Wijnant","sequence":"first","affiliation":[{"name":"London School of Hygiene &amp; Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon L.","family":"Croft","sequence":"additional","affiliation":[{"name":"London School of Hygiene &amp; Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"de la Flor","sequence":"additional","affiliation":[{"name":"Pharmidex Pharmaceutical Services Ltd., London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Alavijeh","sequence":"additional","affiliation":[{"name":"Pharmidex Pharmaceutical Services Ltd., London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Yardley","sequence":"additional","affiliation":[{"name":"London School of Hygiene &amp; Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Braillard","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Disease initiative (DNDi), Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mowbray","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Disease initiative (DNDi), Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-5282","authenticated-orcid":false,"given":"Katrien","family":"Van Bocxlaer","sequence":"additional","affiliation":[{"name":"London School of Hygiene &amp; Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom"},{"name":"York Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007092"},{"key":"e_1_3_3_3_2","first-page":"3","volume-title":"Drug discovery for leishmaniasis","author":"Alvar J","year":"2018","unstructured":"Alvar J, Arana B. 2018. 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