{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:50:27Z","timestamp":1790707827541,"version":"4.1.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Imipenem with relebactam was active against\n Escherichia coli<\/jats:named-content>\n ,\n Klebsiella pneumoniae<\/jats:named-content>\n , and\n Enterobacter<\/jats:named-content>\n spp., including\n K. pneumoniae<\/jats:named-content>\n carbapenemase (KPC)-producing isolates. Loss of OmpK36 in KPC-producing\n K. pneumoniae<\/jats:named-content>\n isolates affected the susceptibility of this combination. Enhanced activity was evident against\n Pseudomonas aeruginosa<\/jats:named-content>\n , including isolates with depressed\n oprD<\/jats:italic>\n and increased\n ampC<\/jats:italic>\n expression. However, the addition of relebactam to imipenem did not provide added benefit against\n Acinetobacter baumannii<\/jats:named-content>\n . The combination of imipenem with relebactam demonstrated activity against KPC-producing\n Enterobacteriaceae<\/jats:named-content>\n and multidrug-resistant\n P. aeruginosa<\/jats:named-content>\n .\n <\/jats:p>","DOI":"10.1128\/aac.00830-15","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T11:24:53Z","timestamp":1432725893000},"page":"5029-5031","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":166,"title":["Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City"],"prefix":"10.1128","volume":"59","author":[{"given":"Amabel","family":"Lapuebla","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olawole","family":"Olafisoye","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Cortes","sequence":"additional","affiliation":[{"name":"Dr. James J. 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Rahal, Jr., Division of Infectious Diseases, New York Hospital Queens, Flushing, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Landman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Quale","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, SUNY Downstate Medical Center, Brooklyn, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00048"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70054-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00826-13"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014556652"},{"key":"e_1_3_2_6_2","volume-title":"Approved standard M100-S24","author":"Clinical and Laboratory Standards Institute","year":"2014","unstructured":"Clinical and Laboratory Standards Institute. 2014. 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