{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:50:55Z","timestamp":1761929455448},"reference-count":36,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            9-(\n            <jats:italic>S<\/jats:italic>\n            )-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [(\n            <jats:italic>S<\/jats:italic>\n            )-HPMPA] has been reported to have antischistosomal activity. Ether lipid esters of (\n            <jats:italic>S<\/jats:italic>\n            )-HPMPA and cidofovir (CDV) have greatly increased activities in antiviral assays and in lethal animal models of poxvirus diseases. To see if ether lipid esters of CDV and (\n            <jats:italic>S<\/jats:italic>\n            )-HPMPA enhance antischistosomal activity, we tested their alkoxyalkyl esters using\n            <jats:italic>Schistosoma mansoni<\/jats:italic>\n            worm killing in vitro. Hexadecyloxypropyl (HDP)-cyclic-(\n            <jats:italic>S<\/jats:italic>\n            )-HPMPA and HDP-cyclic-CDV exhibited significant in vitro antischistosomal activities and may offer promise alone or in combination with praziquantel.\n          <\/jats:p>","DOI":"10.1128\/aac.00840-09","type":"journal-article","created":{"date-parts":[[2009,8,25]],"date-time":"2009-08-25T02:14:08Z","timestamp":1251166448000},"page":"5284-5287","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Antischistosomal Activity of Hexadecyloxypropyl Cyclic 9-(\n            <i>S<\/i>\n            )-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine and Other Alkoxyalkyl Esters of Acyclic Nucleoside Phosphonates Assessed by Schistosome Worm Killing In Vitro"],"prefix":"10.1128","volume":"53","author":[{"given":"Sanaa S.","family":"Botros","sequence":"first","affiliation":[{"name":"Departments of Pharmacology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"William","sequence":"additional","affiliation":[{"name":"Parasitology, Theodor Bilharz Research Institute, Warrak el-Hadar, Imbaba, P.O. 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