{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:24:30Z","timestamp":1769120670165,"version":"3.49.0"},"reference-count":83,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K24 AI114818"],"award-info":[{"award-number":["K24 AI114818"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Polymyxins are last-resort antimicrobial agents used to treat infections caused by carbapenem-resistant\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            . Due to the worldwide dissemination of polymyxin resistance in animal and human isolates, we aimed to characterize polymyxin resistance associated with the presence of\n            <jats:italic>mcr-1<\/jats:italic>\n            in\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            and nonfermenter Gram-negative bacilli, using isolates collected retrospectively in Colombia from 2002 to 2016. A total of 5,887 Gram-negative clinical isolates were studied, and 513 were found to be resistant to the polymyxins. Susceptibility to colistin was confirmed by broth microdilution for all\n            <jats:italic>mcr-1<\/jats:italic>\n            -positive isolates, and these were further subjected to whole-genome sequencing (WGS). The localization of\n            <jats:italic>mcr-1<\/jats:italic>\n            was confirmed by S1 pulsed-field gel electrophoresis (S1-PFGE) and CeuI-PFGE hybridization. Transferability was evaluated by mating assays. A total of 12 colistin-resistant isolates recovered after 2013 harbored\n            <jats:italic>mcr-1<\/jats:italic>\n            , including 8\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            , 3\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovar Typhimurium, and 1\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            isolate\n            <jats:named-content content-type=\"genus-species\">. E. coli<\/jats:named-content>\n            isolates were unrelated by PFGE and belonged to 7 different sequence types (STs) and phylogroups.\n            <jats:italic>S<\/jats:italic>\n            . Typhimurium and\n            <jats:named-content content-type=\"genus-species\">K. pneumoniae<\/jats:named-content>\n            isolates belonged to ST34 and ST307, respectively. The\n            <jats:italic>mcr-1<\/jats:italic>\n            gene was plasmid borne in all isolates but two\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            isolates which harbored it on the chromosome. Conjugation of\n            <jats:italic>mcr-1<\/jats:italic>\n            was successful in 8 of 10 isolates (8.2 \u00d7 10\n            <jats:sup>\u22125<\/jats:sup>\n            to 2.07 \u00d7 10\n            <jats:sup>\u22121<\/jats:sup>\n            cell per recipient). Plasmid sequences showed that the\n            <jats:italic>mcr-1<\/jats:italic>\n            plasmids belonged to four different Inc groups (a new IncP-1 variant and the IncFII, IncHI1, and IncH families). Our results indicate that\n            <jats:italic>mcr-1<\/jats:italic>\n            is circulating in clinical isolates of colistin-resistant\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            in Colombia and is mainly harbored in transferable plasmids.\n          <\/jats:p>","DOI":"10.1128\/aac.00841-17","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:40:28Z","timestamp":1505176828000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Genomic and Molecular Characterization of Clinical Isolates of Enterobacteriaceae Harboring\n            <i>mcr-1<\/i>\n            in Colombia, 2002 to 2016"],"prefix":"10.1128","volume":"61","author":[{"given":"Sandra Yamile","family":"Saavedra","sequence":"first","affiliation":[{"name":"Grupo de Microbiolog\u00eda, Instituto Nacional de Salud (INS), Bogot\u00e1, 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