{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:06:45Z","timestamp":1775722005401,"version":"3.50.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["K23AI185174"],"award-info":[{"award-number":["K23AI185174"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Houston Methodist Hospital | Houston Methodist Research Institute","award":["Clinical Scholars Award"],"award-info":[{"award-number":["Clinical Scholars Award"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,8,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Deep-seated\n              <jats:italic>Candida<\/jats:italic>\n              spp. infections may necessitate extended durations of antifungal therapy. Increasing resistance to first-line antifungals threatens the most common options for long-term treatment. In this issue, Ponta et al. (Antimicrob Agents Chemother 68:e00750-24, 2024,\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1128\/aac.00750-24\" xlink:type=\"simple\">https:\/\/doi.org\/10.1128\/aac.00750-24<\/jats:ext-link>\n              ) present cases in which they used rezafungin, a novel long-acting echinocandin antifungal, for extended durations. While excellent clinical evidence supports the short-term safety of rezafungin, these cases demonstrate that rezafungin may additionally have a role in long-term suppressive therapy for antifungal-resistant\n              <jats:italic>Candida<\/jats:italic>\n              spp. infections.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.00847-24","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T13:00:55Z","timestamp":1721653255000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Case Commentary: Extending our therapeutic range against multidrug-resistant\n            <i>Candida<\/i>"],"prefix":"10.1128","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-6046","authenticated-orcid":false,"given":"Max W.","family":"Adelman","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA"},{"name":"Center for Infectious Diseases, Houston Methodist Research Institute, Houston, Texas, USA"},{"name":"Division of Pulmonary, Critical Care, and Sleep, Department of Medicine, Houston Methodist Hospital, Houston, Texas, USA"},{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-9950","authenticated-orcid":false,"given":"David R.","family":"Andes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, 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