{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:23:59Z","timestamp":1761708239583},"reference-count":11,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro susceptibilities of 151 unique clinical isolates of\n            <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n            ,\n            <jats:italic>Mycoplasma hominis<\/jats:italic>\n            ,\n            <jats:italic>Mycoplasma fermentans<\/jats:italic>\n            ,\n            <jats:italic>Mycoplasma genitalium<\/jats:italic>\n            , and\n            <jats:italic>Ureaplasma<\/jats:italic>\n            species to DC-159a, an investigational fluoroquinolone, in comparison with those to other agents were determined. Macrolides were the most active agents against\n            <jats:italic>M. pneumoniae<\/jats:italic>\n            and\n            <jats:italic>M. genitalium<\/jats:italic>\n            , whereas clindamycin was most active against\n            <jats:italic>M. hominis.<\/jats:italic>\n            DC-159a MICs were \u22640.5 \u03bcg\/ml for all\n            <jats:italic>Mycoplasma<\/jats:italic>\n            species and \u22644 \u03bcg\/ml for ureaplasmas. DC-159a was the most active fluoroquinolone tested against\n            <jats:italic>M. pneumoniae<\/jats:italic>\n            and\n            <jats:italic>M. fermentans<\/jats:italic>\n            , and it was second to moxifloxacin against the other species. It was bactericidal against 10\n            <jats:italic>M. pneumoniae<\/jats:italic>\n            isolates and demonstrated killing of \u226599.9% of the inoculum at 24 h for 2 isolates. The excellent in vitro activity of DC-159a demonstrates its potential for use in the treatment of infections due to mycoplasmas and ureaplasmas.\n          <\/jats:p>","DOI":"10.1128\/aac.00849-08","type":"journal-article","created":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T00:44:55Z","timestamp":1217292295000},"page":"3776-3778","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Comparative In Vitro Activities of the Investigational Fluoroquinolone DC-159a and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas"],"prefix":"10.1128","volume":"52","author":[{"given":"Ken B.","family":"Waites","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Crabb","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn B.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.3.703"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1590-1591.2006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/jac\/dkg365","volume":"52","year":"2003","unstructured":"Duffy, L. B., D. M. Crabb, X. Bing, and K. B. Waites. 2003. Bactericidal activity of levofloxacin against Mycoplasma pneumoniae. J. Antimicrob. Chemother.52:527-528.","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00853-07"},{"key":"e_1_3_2_6_2","unstructured":"DC-159a a new generation of respiratory quinolone: in vitro activities against clinical isolates and its mode of action against topoisomerases abstr. F1-0478. 2006"},{"key":"e_1_3_2_7_2","unstructured":"DC-159a a novel oral quinolone activity tested against community-acquired respiratory tract (CA-RTI) pathogens abstr. F1-0480. 2006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2604-2608.2001"},{"key":"e_1_3_2_9_2","first-page":"649","year":"2001","unstructured":"Waites, K. B. 2001. Mycoplasma, p. 649-655. In D. Schlossberg (ed.), Current therapy of infectious disease, 2nd ed. Mosby-Year Book, Inc., St. Louis, MO.","journal-title":"Current therapy of infectious disease"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.1.161-165.2003"},{"key":"e_1_3_2_11_2","first-page":"3.15.1","year":"2004","unstructured":"Waites, K. B., L. B. Duffy, S. Schwartz, and D. F. Talkington. 2004. Mycoplasma and Ureaplasma, p. 3.15.1-3.15.15. In H. Isenberg (ed.), Clinical microbiology procedures handbook, 2nd ed. ASM Press, Washington, DC.","journal-title":"Clinical microbiology procedures handbook"},{"key":"e_1_3_2_12_2","first-page":"1004","year":"2007","unstructured":"Waites, K. B., and D. Taylor-Robinson. 2007. Mycoplasma and Ureaplasma, p. 1004-1020. In P. R. Murray, E. J. Baron, M. L. Landry, and M. A. Pfaller (ed.), Manual of clinical microbiology, 9th ed. ASM Press, Washington, DC.","journal-title":"Manual of clinical microbiology"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00849-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00849-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:21:19Z","timestamp":1645471279000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00849-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1128\/AAC.00849-08"],"URL":"https:\/\/doi.org\/10.1128\/aac.00849-08","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"2008-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}