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To determine whether the mitochondrial electron transport chain of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Leishmania<\/jats:named-content>\n            parasites could be targeted similarly for drug development, we investigated the activity of 134 structurally diverse ELQs. A cohort of ELQs was selectively toxic to amastigotes of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Leishmania mexicana<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">L. donovani<\/jats:named-content>\n            , with 50% inhibitory concentrations (IC\n            <jats:sub>50<\/jats:sub>\n            s) in the low micromolar range, but the structurally similar hydroxynaphthoquinone buparvaquone was by far the most potent inhibitor of electron transport, ATP production, and intracellular amastigote growth. Cytochrome\n            <jats:italic>bc<\/jats:italic>\n            <jats:sub>1<\/jats:sub>\n            is thus a promising target for novel antileishmanial drugs, and further improvements on the buparvaquone scaffold are warranted for development of enhanced therapeutics.\n          <\/jats:p>","DOI":"10.1128\/aac.00850-16","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T02:34:13Z","timestamp":1465871653000},"page":"4972-4982","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Targeting the Cytochrome\n            <i>bc<\/i>\n            <sub>1<\/sub>\n            Complex of Leishmania Parasites for Discovery of Novel Drugs"],"prefix":"10.1128","volume":"60","author":[{"given":"Diana","family":"Ortiz","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Forquer","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Boitz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radika","family":"Soysa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Elya","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Fulwiler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology, Oregon Health &amp; Science University, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, Portland, Oregon, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamsen","family":"Polley","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology &amp; 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