{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:14:32Z","timestamp":1790763272000,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,7,22]]},"abstract":"<jats:p>\n            The clinical benefit of carbapenems against carbapenemase-producing\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            (CPE) remains in question. MICs of imipenem (IMP) and ertapenem (ERT) against isogenic derivatives of the wild-type strain\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            CFT073 producing KPC-3, OXA-48, or NDM-1 were 0.25, 2, 16, and 64\u2009mg\/liter for IMP and 0.008, 0.5, 8, and 64\u2009mg\/liter for ERT, respectively. Swiss ICR-strain mice with peritonitis were treated for 24 h with IMP or ERT. Despite a limited duration of time during which free antibiotic concentrations were above the MIC (down to 0% for the NDM-1-producing strain), IMP and ERT significantly reduced bacterial counts in spleen and peritoneal fluid at 24 h (\n            <jats:italic>P<\/jats:italic>\n            \u2009&lt;\u20090.\n          <\/jats:p>","DOI":"10.1128\/aac.00853-20","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T12:54:37Z","timestamp":1589460877000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Analysis of Paradoxical Efficacy of Carbapenems against Carbapenemase-Producing Escherichia coli in a Murine Model of Lethal Peritonitis"],"prefix":"10.1128","volume":"64","author":[{"given":"Ariane","family":"Roujansky","sequence":"first","affiliation":[{"name":"IAME UMR-1137, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoire","family":"de Lastours","sequence":"additional","affiliation":[{"name":"IAME UMR-1137, INSERM, Paris, France"},{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Service de m\u00e9decine interne, H\u00f4pital Beaujon, AP-HP, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"CHU de Caen, Service de Microbiologie, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Chau","sequence":"additional","affiliation":[{"name":"IAME UMR-1137, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Cheminet","sequence":"additional","affiliation":[{"name":"IAME UMR-1137, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Massias","sequence":"additional","affiliation":[{"name":"IAME UMR-1137, INSERM, Paris, France"},{"name":"Pharmacie, H\u00f4pital Bichat, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-9912","authenticated-orcid":false,"given":"Vincent","family":"Cattoir","sequence":"additional","affiliation":[{"name":"CHU de Rennes, Service de Bact\u00e9riologie-Hygi\u00e8ne Hospitali\u00e8re &amp; CNR de la R\u00e9sistance aux Antibiotiques (laboratoire associ\u00e9 \u201cEnt\u00e9rocoques\u201d), Rennes, France"},{"name":"Unit\u00e9 Inserm U1230, Universit\u00e9 de Rennes 1, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Fantin","sequence":"additional","affiliation":[{"name":"IAME UMR-1137, INSERM, Paris, France"},{"name":"Universit\u00e9 de Paris, Paris, France"},{"name":"Service de m\u00e9decine interne, H\u00f4pital Beaujon, AP-HP, Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1337508"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00079-17"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02166-13"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12697"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis588"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.01.016"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30521-2"},{"key":"e_1_3_2_9_2","first-page":"297","article-title":"Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics","volume":"8","author":"Zmarlicka MT","year":"2015","unstructured":"Zmarlicka MT, Nailor MD, Nicolau DP. 2015. 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