{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:25:08Z","timestamp":1791523508682,"version":"4.3.4"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,11,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      We evaluated the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant,\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM<\/jats:sub>\n                      -positive\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20\/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-\u03b2-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM-1<\/jats:sub>\n                      . These findings highlight the species-specific limitations of xeruborbactam in\n                      <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00857-25","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:22:55Z","timestamp":1760106175000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-4197","authenticated-orcid":true,"given":"Kaan","family":"Kocer","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t3r8h32","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University of L\u00fcbeck and University Hospital Schleswig-Holstein Campus L\u00fcbeck","place":["L\u00fcbeck, Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-7897","authenticated-orcid":false,"given":"Truong Nhat","family":"My","sequence":"additional","affiliation":[{"name":"Vietnamese-German Centre for Medical Research (VG-CARE)","place":["Hanoi, Vietnam"]},{"id":[{"id":"https:\/\/ror.org\/04k25m262","id-type":"ROR","asserted-by":"publisher"}],"name":"108 Military Central Hospital","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-0114","authenticated-orcid":false,"given":"Bui Tien","family":"Sy","sequence":"additional","affiliation":[{"name":"Vietnamese-German Centre for Medical Research (VG-CARE)","place":["Hanoi, Vietnam"]},{"id":[{"id":"https:\/\/ror.org\/04k25m262","id-type":"ROR","asserted-by":"publisher"}],"name":"108 Military Central Hospital","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"G\u00f6pel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t3r8h32","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University of L\u00fcbeck and University Hospital Schleswig-Holstein Campus L\u00fcbeck","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-9883","authenticated-orcid":false,"given":"Thirumalaisamy P.","family":"Velavan","sequence":"additional","affiliation":[{"name":"Vietnamese-German Centre for Medical Research (VG-CARE)","place":["Hanoi, Vietnam"]},{"id":[{"id":"https:\/\/ror.org\/05ezss144","id-type":"ROR","asserted-by":"publisher"}],"name":"Faculty of Medicine, Duy Tan University","place":["Da Nang, Vietnam"]},{"id":[{"id":"https:\/\/ror.org\/00pjgxh97","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Tropical Medicine, Universit\u00e4tsklinikum T\u00fcbingen","place":["T\u00fcbingen, Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen","place":["T\u00fcbingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Huu","family":"Song","sequence":"additional","affiliation":[{"name":"Vietnamese-German Centre for Medical Research (VG-CARE)","place":["Hanoi, Vietnam"]},{"id":[{"id":"https:\/\/ror.org\/04k25m262","id-type":"ROR","asserted-by":"publisher"}],"name":"108 Military Central Hospital","place":["Hanoi, Vietnam"]},{"id":[{"id":"https:\/\/ror.org\/00pjgxh97","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Tropical Medicine, Universit\u00e4tsklinikum T\u00fcbingen","place":["T\u00fcbingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Peter","sequence":"additional","affiliation":[{"name":"German Center for Infection Research (DZIF), Partner Site T\u00fcbingen","place":["T\u00fcbingen, Germany"]},{"id":[{"id":"https:\/\/ror.org\/00pjgxh97","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology and Hygiene, Universit\u00e4tsklinikum T\u00fcbingen","place":["T\u00fcbingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Boutin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t3r8h32","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University of L\u00fcbeck and University Hospital Schleswig-Holstein Campus L\u00fcbeck","place":["L\u00fcbeck, Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems","place":["L\u00fcbeck, Germany"]},{"id":[{"id":"https:\/\/ror.org\/03dx11k66","id-type":"ROR","asserted-by":"publisher"}],"name":"Airway Research Center North (ARCN), German Center for Lung Research (DZL)","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9203-8801","authenticated-orcid":false,"given":"Adesola","family":"Olalekan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05rk03822","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Medical Laboratory Science, College of Medicine, University of Lagos","place":["Lagos, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1278-5939","authenticated-orcid":true,"given":"Dennis","family":"Nurjadi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00t3r8h32","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medical Microbiology, University of L\u00fcbeck and University Hospital Schleswig-Holstein Campus L\u00fcbeck","place":["L\u00fcbeck, Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg-L\u00fcbeck-Borstel-Riems","place":["L\u00fcbeck, Germany"]},{"name":"Vietnamese-German Centre for Medical Research (VG-CARE)","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.08.029"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00329-9"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.100958"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12406"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00991-23"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01963-19"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00757-20"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00210-21"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae263"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae631.1298"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae631.166"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01570-23"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlad038"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03115-24"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2019.03.003"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02011-21"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00497-24"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab888"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2025.107563"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00118-23"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00297-25"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00857-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00857-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:07:29Z","timestamp":1785884849000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00857-25"}},"subtitle":[],"editor":[{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,5]]}},"alternative-id":["10.1128\/aac.00857-25"],"URL":"https:\/\/doi.org\/10.1128\/aac.00857-25","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"2025-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00857-25"}}