{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:04:53Z","timestamp":1762297493765},"reference-count":15,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            This study compared the efficacies of two\n            <jats:italic>N<\/jats:italic>\n            -methylglucomine antimoniate (MA) dose regimens for treating macaques with\n            <jats:italic>Leishmania braziliensis<\/jats:italic>\n            -induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA\/kg\/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA\/kg\/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.\n          <\/jats:p>","DOI":"10.1128\/aac.00858-09","type":"journal-article","created":{"date-parts":[[2009,10,13]],"date-time":"2009-10-13T01:31:12Z","timestamp":1255397472000},"page":"502-505","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Comparative Efficacies of Two Antimony Regimens To Treat\n            <i>Leishmania braziliensis<\/i>\n            -Induced Cutaneous Leishmaniasis in Rhesus Macaques (\n            <i>Macaca mulatta<\/i>\n            )"],"prefix":"10.1128","volume":"54","author":[{"suffix":"Jr.","given":"G.","family":"Grimaldi","sequence":"first","affiliation":[{"name":"Laborato\u0301rio de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Porrozzi","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Toxicologia Ambiental, Escola Nacional de Sau\u0301de Pu\u0301blica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Teva","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Marchevsky","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Neurovirule\u0302ncia, Instituto de Tecnologia em Imunobiolo\u0301gicos, Fiocruz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Departamento de Qui\u0301mica, Pontifi\u0301cia Universidade Cato\u0301lica do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Miekeley","sequence":"additional","affiliation":[{"name":"Departamento de Qui\u0301mica, Pontifi\u0301cia Universidade Cato\u0301lica do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J. R.","family":"Paumgartten","sequence":"additional","affiliation":[{"name":"Laborato\u0301rio de Toxicologia Ambiental, Escola Nacional de Sau\u0301de Pu\u0301blica"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1031R.1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.3.560"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90267-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2003.09.008"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/510860"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.3126-3132.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762008000700002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1991.45.98"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(89)90173-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.47.117"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-001-1213-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.57.651"},{"key":"e_1_3_2_14_2","first-page":"226","volume":"2","year":"1980","unstructured":"Rees, P. H., M. I. Keating, P. A. Kager, and W. T. Hockmeyer. 1980. Renal clearance of pentavalent antimony (sodium stibogluconate). 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