{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:18:43Z","timestamp":1790864323866,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The production of metallo-\u03b2-lactamase (MBL) is an important mechanism of resistance to \u03b2-lactam antibiotics, including carbapenems. Despite the discovery and emergence of many acquired metallo-\u03b2-lactamases, IMP-type determinants (now counting at least 27 variants) remain the most prevalent in some geographical areas. In Asian countries, and notably Japan, IMP-1 and its closely related variants are most widespread. Some other variants have been detected in other countries and show either an endemic (e.g., IMP-13 in Italy) or sporadic (e.g., IMP-12 in Italy or IMP-18 in the United States) occurrence. The IMP-18-producing\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            strain PS 297 from the southwestern United States carried at least two class 1 integrons. One was identical to In\n            <jats:italic>51<\/jats:italic>\n            , while the other, named In\n            <jats:italic>133<\/jats:italic>\n            and carrying the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>IMP-18<\/jats:sub>\n            gene cassette in the third position, showed an original array of five gene cassettes, including\n            <jats:italic>aacA7<\/jats:italic>\n            ,\n            <jats:italic>qacF<\/jats:italic>\n            ,\n            <jats:italic>aadA1<\/jats:italic>\n            , and an unknown open reading frame (ORF). Interestingly. In\n            <jats:italic>133<\/jats:italic>\n            differed significantly from In\n            <jats:italic>96<\/jats:italic>\n            , the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>IMP-18<\/jats:sub>\n            -carrying integron identified in a\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            isolate from Mexico. The meropenem and ertapenem MIC values were much lower for\n            <jats:italic>Escherichia coli<\/jats:italic>\n            strains producing IMP-18 (0.06 and 0.12 \u03bcg\/ml, respectively) than for strains producing IMP-1 (2 \u03bcg\/ml for each). Kinetic data obtained with the purified enzyme revealed lower turnover rates of IMP-18 than of other IMP-type enzymes with most substrates.\n          <\/jats:p>","DOI":"10.1128\/aac.00858-10","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T04:54:51Z","timestamp":1288673691000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Genetic Context and Biochemical Characterization of the IMP-18 Metallo-\u03b2-Lactamase Identified in a\n            <i>Pseudomonas aeruginosa<\/i>\n            Isolate from the United States"],"prefix":"10.1128","volume":"55","author":[{"given":"Luisa","family":"Borgianni","sequence":"first","affiliation":[{"name":"Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Universita\u0300 di Siena, I-53100, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Prandi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Universita\u0300 di Siena, I-53100, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Salden","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Universita\u0300 di Siena, I-53100, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Santella","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Universita\u0300 di Siena, I-53100, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy D.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Rossolini","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Universita\u0300 di Siena, I-53100, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Denis","family":"Docquier","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Universita\u0300 di Siena, I-53100, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01336-09"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01310-05"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"CLSI document M7-A7. 2006","DOI":"10.1201\/9781420006360.ax7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.155"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05954-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg067"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1522-1528.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.660-663.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00679-07"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.08.003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01440-05"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01102-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp142"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.902"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.4.890"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90224-Y"},{"key":"e_1_3_2_19_2","first-page":"127","year":"2007","unstructured":"Mereuta, A. I., D. T. Buiuc, G. M. Rossolini, and J. D. Docquier. 2007. Simultaneous detection of VIM-2 and IMP-13-producing carbapenem-resistant Pseudomonas aeruginosa clinical isolates from Romania, abstr. C2-1498, p. 127. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.","journal-title":"Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(99)00202-X"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.1.71"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3824-3828.2005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2557"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2217\/17460913.2.5.501"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01456-09"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.5.1229-1235.2000"},{"key":"e_1_3_2_27_2","first-page":"115","year":"2007","unstructured":"Rossolini, G. M., and J. D. Docquier. 2007. Class B \u03b2-lactamases, p. 115-144. In R. A. Bonomo and M. E. Tolmasky (ed.), Enzyme-mediated resistance to antibiotics: mechanisms, dissemination and prospects for inhibition. ASM Press, Washington, DC.","journal-title":"Enzyme-mediated resistance to antibiotics: mechanisms, dissemination and prospects for inhibition."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00824-09"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01337-07"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2005.01.016"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328303670b"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.2.306-325.2005"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01172-08"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00774-09"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00858-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00858-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:54:47Z","timestamp":1645480487000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00858-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1128\/AAC.00858-10"],"URL":"https:\/\/doi.org\/10.1128\/aac.00858-10","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2010-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}