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Aminoglycosides are known to accumulate in the kidneys, but the quantitative relationship between drug exposures and nephrotoxicity is not well established. To bridge the knowledge gap, the objective of this study was to develop an animal model with clinically relevant conditions to mimic human disease progression. Single-dose pharmacokinetics were studied in Sprague-Dawley rats dosed either with 100 or 500\u2009mg\/kg of body weight of amikacin subcutaneously.\n          <\/jats:p>","DOI":"10.1128\/aac.00859-20","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T13:47:23Z","timestamp":1592574443000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of Amikacin Drug Exposure and Nephrotoxicity in an Animal Model"],"prefix":"10.1128","volume":"64","author":[{"given":"Katrina","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly R.","family":"Ledesma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Translational Research, University 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