{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:36:09Z","timestamp":1789994169515,"version":"4.0.1"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Candida<\/jats:italic>infections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of &lt;3 months of age receiving intravenous amphotericin B for documented or highly suspected candidiasis were enrolled in a single-dose (<jats:italic>n<\/jats:italic>= 6) or subsequent multiple-dose (<jats:italic>n<\/jats:italic>= 12) panel; all received caspofungin at 25 mg\/m<jats:sup>2<\/jats:sup>once daily as a 1-hour infusion. Caspofungin plasma levels were measured by high-performance liquid chromatography and compared to historical data from adults. Patient chronological ages ranged from 1 to 11 weeks, and weights ranged from 0.68 to 3.8 kg. Gestational ages ranged from 24 to 41 weeks. Geometric mean (GM) peak (<jats:italic>C<\/jats:italic><jats:sub>1 h<\/jats:sub>) and trough (<jats:italic>C<\/jats:italic><jats:sub>24 h<\/jats:sub>) caspofungin levels were 8.2 and 1.8 \u03bcg\/ml, respectively, on day 1, and 11.1 and 2.4 \u03bcg\/ml, respectively, on day 4. GM ratios for<jats:italic>C<\/jats:italic><jats:sub>1 h<\/jats:sub>and<jats:italic>C<\/jats:italic><jats:sub>24 h<\/jats:sub>for neonates\/infants relative to adults receiving caspofungin at 50 mg\/day were 1.07 and 1.36, respectively, on day 1, and 1.18 and 1.21, respectively, on day 4. Clinical and laboratory adverse events occurred in 17 (94%) and 8 (44%) patients, respectively. Five patients (28%) had serious adverse events, none of which were considered drug related. Caspofungin at 25 mg\/m<jats:sup>2<\/jats:sup>once daily was well tolerated in this group of neonates\/infants of &lt;3 months of age and appears to provide relatively similar plasma exposure to that obtained in adults receiving 50 mg\/day. However, the small number of patients studied precludes any definitive recommendations about caspofungin dosing for this group comprising a broad range of ages and weights.<\/jats:p>","DOI":"10.1128\/aac.00868-08","type":"journal-article","created":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T02:12:18Z","timestamp":1229393538000},"page":"869-875","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":118,"title":["Pharmacokinetics and Safety of Caspofungin in Neonates and Infants Less than 3 Months of Age"],"prefix":"10.1128","volume":"53","author":[{"given":"Xavier","family":"Sa\u0301ez-Llorens","sequence":"first","affiliation":[{"name":"Hospital del Nin\u0303o, Panama City, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Macias","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pediatri\u0301a, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padmanabha","family":"Maiya","sequence":"additional","affiliation":[{"name":"MS Ramaiah Medical College, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Pineros","sequence":"additional","affiliation":[{"name":"Fundacio\u0301n Santa Fe de Bogota\u0301, Bogota\u0301, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan S.","family":"Jafri","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center at Dallas, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Creighton University School of Medicine, Omaha, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Hospital University San Ignacio, Bogota\u0301, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaki","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Kanakamna Ramachandra Hospital, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Kartsonis","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim M.","family":"Strohmaier","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Fallon","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Bi","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Stone","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Chow","sequence":"additional","affiliation":[{"name":"Merck Research Laboratories, West Point, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.451-457.2002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826070500271915"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0146-0005(03)00060-0","volume":"27","year":"2003","unstructured":"Bliss, J. 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