{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:40:09Z","timestamp":1767166809260,"version":"build-2238731810"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"National Women Young Bioscientist Award, Department of Biotechnology (DBT), Government of India","award":["BT\/HRD\/NBA\/37\/01\/2014 (xii)"],"award-info":[{"award-number":["BT\/HRD\/NBA\/37\/01\/2014 (xii)"]}]},{"name":"Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India","award":["EMR\/2016\/005375"],"award-info":[{"award-number":["EMR\/2016\/005375"]}]},{"DOI":"10.13039\/501100009053","name":"Wellcome Trust\/DBT India Alliance","doi-asserted-by":"crossref","award":["IA\/S\/15\/1\/501831"],"award-info":[{"award-number":["IA\/S\/15\/1\/501831"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>\n                    Increasing resistance of the human opportunistic fungal pathogen\n                    <jats:named-content content-type=\"genus-species\">Candida glabrata<\/jats:named-content>\n                    toward the echinocandin antifungals, which target the cell wall, is a matter of grave clinical concern. Echinocandin resistance in\n                    <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n                    has primarily been associated with mutations in the \u03b2-glucan synthase-encoding genes\n                    <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n                    <jats:italic>FKS1<\/jats:italic>\n                    (\n                    <jats:italic>CgFKS1<\/jats:italic>\n                    ) and\n                    <jats:italic>CgFKS2<\/jats:italic>\n                    . This notwithstanding, the role of the phosphoinositide signaling in antifungal resistance is just beginning to be deciphered.\n                  <\/jats:p>","DOI":"10.1128\/aac.00886-19","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T09:30:36Z","timestamp":1558603836000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Essential Role for the Phosphatidylinositol 3,5-Bisphosphate Synthesis Complex in Caspofungin Tolerance and Virulence in\n                    <i>Candida glabrata<\/i>"],"prefix":"10.1128","volume":"63","author":[{"given":"Deepak Kumar","family":"Choudhary","sequence":"first","affiliation":[{"name":"Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana State, 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