{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:25:10Z","timestamp":1791523510326,"version":"4.3.4"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      A 65-year-old man without identifiable risk factors for multidrug-resistant pathogens was admitted with peritonitis, isolating NDM-producing\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      from a rectal swab and intraoperative samples. After surgery, ceftazidime-avibactam\/aztreonam was administered. Due to poor clinical response, he was switched to imipenem-relebactam\/aztreonam, resulting in a successful outcome. Whole-genome sequencing detected\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM-5<\/jats:sub>\n                      and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CMY-148<\/jats:sub>\n                      \u03b2-lactamases, PBP3 YRIN insertion, and mutated\n                      <jats:italic toggle=\"yes\">cirA<\/jats:italic>\n                      gene. This case illustrates the importance of considering different mechanisms of resistance when choosing combination therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00887-25","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T14:00:10Z","timestamp":1771596010000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Optimizing target inactivation to treat multidrug-resistant\n                    <i>Escherichia coli<\/i>\n                    with NDM and PBP3 mutations: \u201cgoing the extra mile\u201d"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-490X","authenticated-orcid":true,"given":"Claudia","family":"Fabrizio","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Clinic, San Giuseppe Moscati Hospital","place":["Taranto, 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