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In this study, we compared the effectiveness of montelukast and zileuton as adjuvant strategies to reduce vancomycin-associated nephrotoxicity. Montelukast only had a marginal effect in vancomycin-treated animals, whereas zileuton significantly delayed nephrotoxicity onset. These findings support further formulation and dose-optimization studies to repurpose zileuton as a renal-protective adjuvant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00887-26","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:08:27Z","timestamp":1789049307000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Comparative adjuvant therapy to reduce vancomycin-associated nephrotoxicity in an animal model"],"prefix":"10.1128","volume":"70","author":[{"given":"Yongqi","family":"Xiao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/048sx0r50","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy","place":["Houston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas 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