{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:29:47Z","timestamp":1787016587353,"version":"build-2736575974"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202585"],"award-info":[{"award-number":["82202585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY288"],"award-info":[{"award-number":["2022KY288"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,12,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Two episodes of imipenem\/relebactam and ceftazidime\/avibactam co-resistant\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      infections were identified in a Chinese hospital with an 8-month interval. All strains belonged to the ST11-KL64 clone, with pairwise SNP distances ranging from 1 to 9, indicating clonal spread. Plasmid-borne\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>KPC-157<\/jats:sub>\n                      (KPC-2 N132S substitution) and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>CTX-M-249<\/jats:sub>\n                      (CTX-M-65 S130G\/P167S substitutions) conferred resistance to imipenem\/relebactam and ceftazidime\/avibactam, respectively. The emergence of these novel resistance determinants in the high-risk clone underscores the need for enhanced surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00891-25","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T11:57:29Z","timestamp":1762257449000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Emergence of co-resistance to imipenem\/relebactam and ceftazidime\/avibactam in clinical\n                    <i>Klebsiella pneumoniae<\/i>\n                    ST11 clone due to KPC-2 N132S and CTX-M-65 S130G\/P167S substitutions"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-7994","authenticated-orcid":false,"given":"Yiqi","family":"Fu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0232r4451","id-type":"ROR","asserted-by":"publisher"}],"name":"Department 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