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A key mechanism that provides extensive resistance to \u03b2-lactam antibiotics is the inducible expression of AmpC \u03b2-lactamase. Recently, a number of clinical isolates expressing mutated forms of AmpC have been found to be clinically resistant to the antipseudomonal \u03b2-lactam\u2013\u03b2-lactamase inhibitor (BLI) combinations ceftolozane-tazobactam and ceftazidime-avibactam.\n          <\/jats:p>","DOI":"10.1128\/aac.00894-20","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T13:21:42Z","timestamp":1594214502000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":54,"title":["Adding Insult to Injury: Mechanistic Basis for How AmpC Mutations Allow Pseudomonas aeruginosa To Accelerate Cephalosporin Hydrolysis and Evade Avibactam"],"prefix":"10.1128","volume":"64","author":[{"given":"Cole L.","family":"Slater","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Winogrodzki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Fraile-Ribot","sequence":"additional","affiliation":[{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Patolog\u00eda Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Son Espases, Instituto de Investigaci\u00f3n Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-1894","authenticated-orcid":false,"given":"Antonio","family":"Oliver","sequence":"additional","affiliation":[{"name":"Red Espa\u00f1ola de Investigaci\u00f3n en Patolog\u00eda Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Son Espases, Instituto de Investigaci\u00f3n Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazdak","family":"Khajehpour","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-1355","authenticated-orcid":false,"given":"Brian L.","family":"Mark","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2015.10.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02671-16"},{"key":"e_1_3_3_5_2","unstructured":"World Health Organization. 27 February 2017. 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