{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:53:58Z","timestamp":1792598038317,"version":"4.5.0"},"reference-count":28,"publisher":"American Society for Microbiology","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100005869","name":"University of Fribourg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Oral ceftibuten and tebipenem, alone or combined with avibactam, ledaborbactam, or xeruborbactam, were evaluated against recombinant\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      producing 57 acquired \u03b2-lactamases. Tebipenem showed greater intrinsic activity than ceftibuten against extended-spectrum \u03b2-lactamase (ESBL) and AmpC producers. Whereas avibactam and ledaborbactam remained inactive against metallo-\u03b2-lactamases, xeruborbactam restored activity against most class B producers. Tebipenem-xeruborbactam demonstrated the broadest inhibitory spectrum and the lowest MIC values overall. This combination may represent a promising oral option for complicated urinary tract infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00905-26","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:12:28Z","timestamp":1792595548000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Activity of oral \u03b2-lactams, tebipenem and ceftibuten, combined with novel oral \u03b2-lactamase inhibitors against broad-spectrum \u03b2-lactamase-producing\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-5576","authenticated-orcid":true,"given":"Christophe","family":"Le Terrier","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/022fs9h90","id-type":"ROR","asserted-by":"publisher"}],"name":"Emerging Antibiotic Resistance Unit, Medical and Molecular 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Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00876-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.ARBA-0026-2017"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01092-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.11.025"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaf460"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00862-20"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2805.212535"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01180-3"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2105462"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02057-22"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-023-04562-4"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00339-23"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00775-24"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00552-21"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00437"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01976"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00533-25"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00297-25"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02168-21"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00195-26"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00547-23"},{"key":"e_1_3_3_26_2","unstructured":"European 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MIC determination. Available from: https:\/\/www.eucast.org\/ast_of_bacteria\/mic_determination"},{"key":"e_1_3_3_27_2","unstructured":"European committee on antimicrobial susceptibility testing (EUCAST). 2026. 2026. Clinical Breakpoint Table v. 16.0. https:\/\/www.eucast.org\/fileadmin\/eucast\/pdf\/breakpoints\/v_16.0_Breakpoint_Tables.pdf."},{"key":"e_1_3_3_28_2","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2025. 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