{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:11:23Z","timestamp":1778742683495,"version":"3.51.4"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>\n            Levonadifloxacin is a novel benzoquinolizine subclass of fluoroquinolone, active against quinolone-resistant\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            . A phase 3 trial for levonadifloxacin and its oral prodrug was recently completed. The present study identified area under the concentration-time curve for the free, unbound fraction of a drug divided by the MIC (\n            <jats:italic>f<\/jats:italic>\n            AUC\/MIC) as an efficacy determinant for levonadifloxacin in a neutropenic murine lung infection model.\n          <\/jats:p>","DOI":"10.1128\/aac.00909-19","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T12:49:47Z","timestamp":1560343787000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["<i>In Vivo<\/i>\n            Pharmacokinetic\/Pharmacodynamic Targets of Levonadifloxacin against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model"],"prefix":"10.1128","volume":"63","author":[{"given":"Sachin S.","family":"Bhagwat","sequence":"first","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hariharan","family":"Periasamy","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapna S.","family":"Takalkar","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Chavan","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan","family":"Tayde","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amol","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaikumar","family":"Satav","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineet","family":"Zope","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Wockhardt Research Centre, Aurangabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm050035f"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00641-06"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01150-08"},{"key":"e_1_3_2_5_2","volume-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"CLSI","year":"2018","unstructured":"CLSI. 2018. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00647-16"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.46.6.1665-1670.2002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3935-3941.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02297-17"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a38.x"},{"key":"e_1_3_2_11_2","volume-title":"WCK 771 (levonadifloxacin): pharmacodynamic index and target determination studies for MRSA\/QRSA employing neutropenic mouse ling infection model","author":"Tayde P","year":"2019","unstructured":"Tayde P, Umarkar K, Kulkarni A, Satav J, Takalhar S, Hariharan P, Chavan R, Zope V, Bhagwat S, Patel M. 2019. WCK 771 (levonadifloxacin): pharmacodynamic index and target determination studies for MRSA\/QRSA employing neutropenic mouse ling infection model, ePoster O1063. ECCMID, Amsterdam, Netherlands."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00909-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00909-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:29:20Z","timestamp":1645478960000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00909-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1128\/AAC.00909-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.00909-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"2019-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00909-19"}}