{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:08:04Z","timestamp":1790644084616,"version":"4.1.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We describe the activity of a novel cephalosporin, CXA-101 (FR26 4205), against a panel of highly resistant\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            isolates collected from U.S. hospitals. CXA-101 demonstrated increased potency against this population of resistant isolates, with activity that is 4- to 10-fold higher than that of comparator agents in each phenotypic category. The addition of tazobactam did not improve its activity. CXA-101 appears to be a promising addition to the category of antipseudomonal \u03b2-lactams.\n          <\/jats:p>","DOI":"10.1128\/aac.00912-09","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T02:57:00Z","timestamp":1258426620000},"page":"557-559","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["<i>In Vitro<\/i>\n            Potency of CXA-101, a Novel Cephalosporin, against\n            <i>Pseudomonas aeruginosa<\/i>\n            Displaying Various Resistance Phenotypes, Including Multidrug Resistance"],"prefix":"10.1128","volume":"54","author":[{"given":"Catharine C.","family":"Bulik","sequence":"first","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford, Connecticut 06102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Christensen","sequence":"additional","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford, Connecticut 06102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford, Connecticut 06102"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2009.01.026"},{"key":"e_1_3_2_3_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard 2008"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L473"},{"key":"e_1_3_2_5_2","unstructured":"Clin. 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