{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T20:06:40Z","timestamp":1776456400284,"version":"3.51.2"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Combining voriconazole and flucloxacillin is indicated in patient cohorts experiencing both invasive aspergillosis and Gram-positive infections (e.g., patients with chronic granulomatous disease or postinfluenza pulmonary aspergillosis). We report a highly relevant interaction between voriconazole and flucloxacillin, resulting in subtherapeutic plasma voriconazole concentrations in more than 50% of patients, that poses a severe threat if not managed properly.<\/jats:p>","DOI":"10.1128\/aac.00915-17","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:40:21Z","timestamp":1500338421000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations"],"prefix":"10.1128","volume":"61","author":[{"given":"Eline W.","family":"Muilwijk","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Radboud university medical center, Nijmegen, The Netherlands"},{"name":"Center of Expertise in Mycology Radboudumc\/CWZ and Radboud Institute of Health Science, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart G. J.","family":"Dekkers","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Centre Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie S. V.","family":"Henriet","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology Radboudumc\/CWZ and Radboud Institute of Health Science, Nijmegen, The Netherlands"},{"name":"Department of Pediatric Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Center of Expertise in Mycology Radboudumc\/CWZ and Radboud Institute of Health Science, Nijmegen, The Netherlands"},{"name":"Department of Medical Microbiology, Radboud university medical center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bregje","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacy, VU University Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M. L. 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