{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:38:13Z","timestamp":1790865493828,"version":"4.1.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in\n                    <jats:italic>Rv0678<\/jats:italic>\n                    and had increased MICs associated with cross-resistance to clofazimine during treatment.\n                  <\/jats:p>","DOI":"10.1128\/aac.00915-19","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T05:33:33Z","timestamp":1561700013000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan"],"prefix":"10.1128","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-1573","authenticated-orcid":false,"given":"Arash","family":"Ghodousi","sequence":"first","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alamdar Hussain","family":"Rizvi","sequence":"additional","affiliation":[{"name":"National TB Reference laboratory, National TB Control Program, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurangzaib Quadir","family":"Baloch","sequence":"additional","affiliation":[{"name":"National TB Control Program, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Ghafoor","sequence":"additional","affiliation":[{"name":"National TB Control Program, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Masood","family":"Khanzada","sequence":"additional","affiliation":[{"name":"National TB Reference laboratory, National TB Control Program, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmood","family":"Qadir","sequence":"additional","affiliation":[{"name":"National TB Reference laboratory, National TB Control Program, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-5119","authenticated-orcid":false,"given":"Emanuele","family":"Borroni","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-5762","authenticated-orcid":false,"given":"Alberto","family":"Trovato","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabira","family":"Tahseen","sequence":"additional","affiliation":[{"name":"National TB Reference laboratory, National TB Control Program, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6415-1535","authenticated-orcid":false,"given":"Daniela Maria","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"WHO consolidated guidelines on drug-resistant tuberculosis treatment","author":"WHO","year":"2019","unstructured":"WHO. 2019. 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