{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:49:50Z","timestamp":1792705790241,"version":"4.5.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI100291"],"award-info":[{"award-number":["R01-AI100291"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Penicillin binding protein 4 (PBP4) can provide high-level \u03b2-lactam resistance in\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            . A series of missense and promoter mutations associated with\n            <jats:italic>pbp4<\/jats:italic>\n            were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the \u03b2-lactam resistance mediated by PBP4 and the promoter mutations lead to overexpression of\n            <jats:italic>pbp4<\/jats:italic>\n            . Our results also suggest a cooperative interplay among PBPs for \u03b2-lactam resistance.\n          <\/jats:p>","DOI":"10.1128\/aac.00932-17","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T00:40:16Z","timestamp":1502757616000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["PBP4 Mediates \u03b2-Lactam Resistance by Altered Function"],"prefix":"10.1128","volume":"61","author":[{"given":"Som S.","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Division of HIV\/AIDS, Infectious Diseases and Global Health, Department of Medicine, University of California, San Francisco, San Francisco General Hospital, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers 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