{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:50:05Z","timestamp":1787759405665,"version":"build-2784847793"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"United States Department of Defense Armed Forces Health Surveillance Division-Global Emerging Infectious Disease Surveillance Branch","award":["P0011_25_AF"],"award-info":[{"award-number":["P0011_25_AF"]}]},{"name":"Military Infectious Diseases Research program","award":["Q0476_19_AF_CS_OC"],"award-info":[{"award-number":["Q0476_19_AF_CS_OC"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,12,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      is an increasing cause of chronic wound infections, especially in military operational settings, and is resistant to many currently available antimicrobial therapies, making treatment options limited. We evaluated the\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity of omadacycline against\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      clinical isolates as well as the\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      efficacy of omadacycline in mice against the multi-drug resistant (MDR)\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      strain 5075 using both a neutropenic thigh infection model and a dorsal wound model of chronic infection relative to the standard of care drugs tigecycline and doxycycline, respectively. Omadacycline demonstrated efficacy against these two established preclinical models of MDR\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      infection in mice. In the dorsal wound infection model, the most efficacious dose tested (10 mg\/kg twice daily for 6 days) resulted in 100% survival, complete clearance of systemic infection, accelerated wound closure, absence of toxicity, significantly reduced inflammatory cytokine responses, and reduced biofilm formation. These results underscore the potential of omadacycline as a promising therapeutic option for combating MDR\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      infections in chronic wound settings and that additional research is warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00932-25","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:01:03Z","timestamp":1761829263000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Preclinical\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    evaluation of omadacycline against multidrug-resistant\n                    <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6375-5814","authenticated-orcid":false,"given":"Pattaraporn","family":"Vanachayangkul","sequence":"first","affiliation":[{"name":"Department of Bacterial and Parasitic Diseases, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-0480","authenticated-orcid":true,"given":"Nattaya","family":"Ruamsap","sequence":"additional","affiliation":[{"name":"Department of Bacterial and Parasitic Diseases, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science","place":["Bangkok, 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The anti-inflammatory effects of tetracyclines. 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