{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:11:52Z","timestamp":1789517512344,"version":"build-2803163510"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cycling of\n            <jats:italic>Streptococcus gordonii<\/jats:italic>\n            (115 times) with penicillin resulted in a MIC increase of more than 100-fold, from 0.008 to 2 \u03bcg\/ml. The 2-\u03bcg\/ml MIC maximum was already reached after 36 passages but resulted in impaired fitness. Although the MIC did not increase further, fitness was partially recovered during the 79 additional cycles.\n          <\/jats:p>","DOI":"10.1128\/aac.00939-07","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T01:23:33Z","timestamp":1195003413000},"page":"337-339","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Fitness Cost and Impaired Survival in Penicillin-Resistant\n            <i>Streptococcus gordonii<\/i>\n            Isolates Selected in the Laboratory"],"prefix":"10.1128","volume":"52","author":[{"given":"Marisa","family":"Haenni","sequence":"first","affiliation":[{"name":"Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Moreillon","sequence":"additional","affiliation":[{"name":"Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)00005-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3949"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1479"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/335351a0"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2295-2297.2004"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.829"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01127-06"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00677-06"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00676-06"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050160"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03173.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.1.33"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(90)90060-4"},{"key":"e_1_3_1_15_2","first-page":"120","volume":"381","year":"1996","unstructured":"Schrag, S. J., and V. Perrot. 1996. Reducing antibiotic resistance. 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