{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:51:05Z","timestamp":1790729465237,"version":"4.1.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Daptomycin is a novel lipopeptide antibiotic with excellent activity against Gram-positive bacterial pathogens, but its therapeutic value for the treatment of invasive pneumococcal disease compared to that for the treatment of pneumococcal pneumonia is incompletely defined. We investigated the efficacy of daptomycin in two models of\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            -induced lung infection, i.e., pneumococcal pneumonia and septic pneumococcal disease. Mice were infected with a bioluminescent, invasive serotype 2\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            strain or a less virulent serotype 19\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            strain and were then given semitherapeutic or therapeutic daptomycin or ceftriaxone. Readouts included survival; bacterial loads; and septic disease progression, as determined by biophotonic imaging. Semitherapeutic daptomycin treatment fully protected the mice against the progression of septic disease induced by serotype 2\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            , while therapeutic treatment of the mice with daptomycin or ceftriaxone led to \u223c70% or \u223c60% survival, respectively. In contrast, mice infected with serotype 19\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            developed severe pneumonia and lung leakage even in the presence of increased intra-alveolar daptomycin levels, resulting in only 40% survival, whereas the ceftriaxone-treated mice had 100% survival. Together, although daptomycin demonstrates little efficacy in the treatment of pneumococcal pneumonia, daptomycin is highly effective in preventing\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            -induced septic death, thus possibly offering a therapeutic option for patients with life-threatening septic pneumococcal disease.\n          <\/jats:p>","DOI":"10.1128\/aac.00943-09","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T02:57:00Z","timestamp":1258426620000},"page":"707-717","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy Profiles of Daptomycin for Treatment of Invasive and Noninvasive Pulmonary Infections with\n            <i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Stefanie","family":"Henken","sequence":"first","affiliation":[{"name":"Clinic for Pulmonary Medicine, Department of Experimental Lung Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bohling","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonary Medicine, Department of Experimental Lung Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Martens-Lobenhoffer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Paton","sequence":"additional","affiliation":[{"name":"Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. David","family":"Ogunniyi","sequence":"additional","affiliation":[{"name":"Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Briles","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Alabama, Birmingham, Alabama 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyvyan C.","family":"Salisbury","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, University of the West of England, Bristol, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Wedekind","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie M.","family":"Bode-Bo\u0308ger","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Welsh","sequence":"additional","affiliation":[{"name":"Novartis Pharma GmbH, Nu\u0308rnberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz C.","family":"Bange","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Epidemiology, Hannover School of Medicine, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Welte","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonary Medicine, Department of Experimental Lung Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich A.","family":"Maus","sequence":"additional","affiliation":[{"name":"Clinic for Pulmonary Medicine, Department of Experimental Lung Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.7.1001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg334"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.02.031"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1919-1922.2001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.2.538-542.2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/376571"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3928-3933.2004"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.9.1351"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.04.006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767100-00008"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00076-06"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.12.006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/596051"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01161-07"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.09.019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2009055"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2112012"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1533OC"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00453.2001"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3273"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27757-0"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540310015854"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/533441"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02724.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000109868"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/430352"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1799-1802.2001"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2538-2544.2003"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh546"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.4.523"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.8.8.1223"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000108106"},{"key":"e_1_3_2_34_2","first-page":"93","volume":"82","year":"2007","unstructured":"WHO. 2007. 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