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TBAJ-587 is a novel diarylquinoline, which shows higher anti-tuberculosis activity, lower lipophilicity, and weaker inhibition of hERG channels than bedaquiline (BDQ). The susceptibilities of 11 NTM reference strains and 194 clinical\n              <jats:italic>Mycobacterium abscessus<\/jats:italic>\n              isolates to TBAJ-587 were determined by the broth microdilution assay. The activity of TBAJ-587 toward the growth of\n              <jats:italic>M. abscessus<\/jats:italic>\n              in macrophages was also evaluated. Minimum bactericidal concentration and time-kill kinetic assays were conducted to distinguish between the bactericidal and bacteriostatic activities of TBAJ-587. The synergy between TBAJ-587 and eight clinically important antibiotics was determined using a checkerboard assay. TBAJ-587 was highly effective against\n              <jats:italic>M. abscessus<\/jats:italic>\n              by targeting its F-ATP synthase\n              <jats:italic>c<\/jats:italic>\n              chain. The antimicrobial activities of TBAJ-587 and BDQ toward intracellular\n              <jats:italic>M. abscessus<\/jats:italic>\n              were comparable. The\n              <jats:italic>in vivo<\/jats:italic>\n              activities of TBAJ-587 and BDQ in an immunocompromised mouse model were also comparable. TBAJ-587 expressed bactericidal activity and was compatible with eight anti-NTM drugs commonly used in clinical practice; no antagonism was discovered. As such, TBAJ-587 represents a potential candidate for the treatment of NTM infections.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.00945-24","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T13:00:38Z","timestamp":1730206838000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["TBAJ-587, a novel diarylquinoline, is active against\n            <i>Mycobacterium abscessus<\/i>"],"prefix":"10.1128","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5143-2968","authenticated-orcid":false,"given":"Junsheng","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","place":["Shanghai, China"]},{"name":"School of Medicine, Tongji University","place":["Shanghai, 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