{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:21:31Z","timestamp":1793157691637,"version":"4.5.0"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Chromosomally encoded \u00df-lactamases from the\n            <jats:italic>Burkholderia cepacia<\/jats:italic>\n            complex species (formerly\n            <jats:italic>Pseudomonas cepacia<\/jats:italic>\n            ) were characterized. Cloning and sequencing identified an Ambler class A \u00df-lactamase (PenB) from\n            <jats:italic>B. cenocepacia.<\/jats:italic>\n            It shares 82% amino acid identity with the PenA \u00df-lactamases previously identified from\n            <jats:italic>B. multivorans<\/jats:italic>\n            249. Its expression was dependent upon a LysR-type regulatory protein. Its narrow-spectrum hydrolysis activity mostly included penicillins but also included expanded-spectrum cephalosporins and aztreonam at lower levels. In that study, Pen-like \u00df-lactamases (PenC, PenD, PenE, PenF) that shared 63 to 92% identity with PenB from\n            <jats:italic>B. cenocepacia<\/jats:italic>\n            were identified from other\n            <jats:italic>Burkholderia<\/jats:italic>\n            species. The corresponding \u00df-lactamase genes might be used as genetic tools for accurate\n            <jats:italic>Burkholderia<\/jats:italic>\n            species identification.\n          <\/jats:p>","DOI":"10.1128\/aac.00946-08","type":"journal-article","created":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T02:12:18Z","timestamp":1229393538000},"page":"876-882","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":56,"title":["Naturally Occurring Class A \u00df-Lactamases from the\n            <i>Burkholderia cepacia<\/i>\n            Complex"],"prefix":"10.1128","volume":"53","author":[{"given":"Laurent","family":"Poirel","sequence":"first","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine et Universite\u0301 Paris-Sud, K.-Bice\u0302tre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301-Manuel","family":"Rodriguez-Martinez","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine et Universite\u0301 Paris-Sud, K.-Bice\u0302tre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ple\u0301siat","sequence":"additional","affiliation":[{"name":"Laboratoire de Bacte\u0301riologie, Faculte\u0301 de Me\u0301decine, Besanc\u0327on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine et Universite\u0301 Paris-Sud, K.-Bice\u0302tre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2760269"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1102.030684"},{"key":"e_1_3_2_4_2","first-page":"44","year":"2004","unstructured":"Bellis, G., M. 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