{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:59:31Z","timestamp":1792004371906,"version":"4.4.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100015511","name":"Wockhardt Bio AG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015511","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n            We evaluated the\n            <jats:italic>in vivo<\/jats:italic>\n            efficacy of human-simulated WCK 5222 (cefepime-zidebactam) against cefepime-resistant\n            <jats:named-content content-type=\"genus-species\">Acinetobacter baumannii<\/jats:named-content>\n            strains (\n            <jats:italic>n<\/jats:italic>\n            = 13) in the neutropenic murine lung infection model. Twelve isolates were meropenem resistant.\n          <\/jats:p>","DOI":"10.1128\/aac.00948-18","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T10:52:49Z","timestamp":1535539969000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Assessment of the\n            <i>In Vivo<\/i>\n            Efficacy of WCK 5222 (Cefepime-Zidebactam) against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Murine Lung Infection Model"],"prefix":"10.1128","volume":"62","author":[{"given":"Lindsay M.","family":"Avery","sequence":"first","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilia","family":"Abdelraouf","sequence":"additional","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA"},{"name":"Division of Infectious Diseases, Hartford Hospital, Hartford, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-017-0149-y"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2013.01.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw593"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx050"},{"key":"e_1_3_2_6_2","volume-title":"Cefepime (FEP) and zidebactam (ZID) mediated dual PBP engagement at sub-MIC concentrations drive cidality against diverse \u03b2-lactamase expressing Gram-negatives, abstr 448","author":"Palwe SR","year":"2016","unstructured":"Palwe SR, Biniwale SS, Khande HN, Joshi PR, Bhagwat SS, Patel MV. 2016. Cefepime (FEP) and zidebactam (ZID) mediated dual PBP engagement at sub-MIC concentrations drive cidality against diverse \u03b2-lactamase expressing Gram-negatives, abstr 448. ASM Microbe 2016, 16 to 20 June 2016, Boston, MA."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02161-13"},{"key":"e_1_3_2_8_2","volume-title":"CLSI document M100","author":"Clinical and Laboratory Standards Institute","year":"2018","unstructured":"Clinical and Laboratory Standards Institute. 2018. Performance standards for antimicrobial susceptibility testing, 28th ed. CLSI document M100. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"28"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06121-11"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4249"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01022-17"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00055"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2015.1095180"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/516284"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.05.021"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00491-17"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01208-16"},{"key":"e_1_3_2_18_2","volume-title":"WCK 5222: unravelling sub-MIC PD effects employing in vivo dose fractionation studies and translating into MIC based PK\/PD target for carbapenem-resistant A. baumannii, abstr P282","author":"Bhagwat SS","year":"2017","unstructured":"Bhagwat SS, Takalkar SS, Chavan RP, Friedland HD, Patel MV. 2017. WCK 5222: unravelling sub-MIC PD effects employing in vivo dose fractionation studies and translating into MIC based PK\/PD target for carbapenem-resistant A. baumannii, abstr P282. ASM Microbe 2017, 1 to 5 June 2017, New Orleans, LA."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00948-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00948-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:18:04Z","timestamp":1645478284000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00948-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1128\/AAC.00948-18"],"URL":"https:\/\/doi.org\/10.1128\/aac.00948-18","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"2018-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00948-18"}}