{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:47:42Z","timestamp":1792608462037,"version":"4.5.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,1,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Candida albicans<\/jats:italic>\n            is responsible for conditions ranging from superficial infections such as oral or vaginal candidiasis to potentially fatal systemic infections. It produces pathogenic factors contributing to its virulence. Iturin A, a lipopeptide derived from\n            <jats:italic>Bacillus<\/jats:italic>\n            sp., exhibits a significant inhibitory effect against\n            <jats:italic>C. albicans<\/jats:italic>\n            . However, its exact mechanism in mitigating the pathogenic factors of\n            <jats:italic>C. albicans<\/jats:italic>\n            remains to be elucidated. This study aimed to explore the influence of iturin A on several pathogenic attributes of\n            <jats:italic>C. albicans<\/jats:italic>\n            , including hypha formation, cell membrane permeability, cell adhesion, biofilm formation, and therapeutic efficacy in an oral\n            <jats:italic>C. albicans<\/jats:italic>\n            infection model in mice. The minimal inhibitory concentration of iturin A against\n            <jats:italic>C. albicans<\/jats:italic>\n            was determined to be 25 \u00b5g\/mL in both YEPD and RPMI-1640 media. Iturin A effectively inhibited\n            <jats:italic>C. albicans<\/jats:italic>\n            hyphal formation, decreased cell viability within biofilms, enhanced cell membrane permeability, and disrupted cell adhesion\n            <jats:italic>in vitro<\/jats:italic>\n            . Nonetheless, iturin A did not significantly affect the phospholipase activity or hydrophobicity of\n            <jats:italic>C. albicans<\/jats:italic>\n            . A comparative study with nystatin demonstrated the superior therapeutic efficacy of iturin A in a mouse model of oral\n            <jats:italic>C. albicans<\/jats:italic>\n            infection, significantly decreasing\n            <jats:italic>C. albicans<\/jats:italic>\n            count and inhibiting both fungal hypha formation and tongue surface adhesion. High-dose iturin A treatment (25 \u00b5g\/mL) in mice had no significant effects on blood indices, tongue condition, or body weight, indicating the potential for iturin A in managing oral infections. This study confirmed the therapeutic potential of iturin A and provided valuable insights for developing effective antifungal therapies targeting\n            <jats:italic>C. albicans<\/jats:italic>\n            pathogenic factors.\n          <\/jats:p>","DOI":"10.1128\/aac.00948-23","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T14:00:16Z","timestamp":1701784816000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Therapeutic effect of iturin A on\n            <i>Candida albicans<\/i>\n            oral infection and its pathogenic factors"],"prefix":"10.1128","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7323-9774","authenticated-orcid":false,"given":"Di","family":"Han","sequence":"first","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saixue","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Song","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Xi\u2019an International University , Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Solidi\ufb01cation Processing, Center for Nano Energy Materials, School of Materials Science and Engineering, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-4225","authenticated-orcid":false,"given":"Chunmei","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Northwestern Polytechnical University , Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01915-07"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.22913"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.112073"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.11.019"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2018.10.057"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.486412"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01159-9"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2010.09.001"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2729-2735.2005"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17625"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.05.012"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-642-14490-5_3","article-title":"Surfactin and other lipopeptides from Bacillus spp","author":"Jacques P","year":"2011","unstructured":"Jacques P . 2011. 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