{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:56:41Z","timestamp":1769021801414,"version":"3.49.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We examined the cerebrospinal fluid penetration of daptomycin after the addition of dexamethasone and its bactericidal efficacy with and without ceftriaxone in an experimental rabbit model of pneumococcal meningitis. The combination of daptomycin with ceftriaxone was the most efficacious regimen for pneumococcal meningitis. The previous addition of dexamethasone affected the antibacterial activity of daptomycin only marginally, either as monotherapy or combined with ceftriaxone, although the penetration of daptomycin into inflamed meninges was significantly reduced from 6 to 2%. Daptomycin with ceftriaxone might be a potential candidate for the empirical therapy of bacterial meningitis, although the activity of this regimen against\n            <jats:italic>Listeria monocytogenes<\/jats:italic>\n            remains to be demonstrated.\n          <\/jats:p>","DOI":"10.1128\/aac.00952-08","type":"journal-article","created":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:33:44Z","timestamp":1239669224000},"page":"3030-3033","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Combination of Daptomycin plus Ceftriaxone Is More Active than Vancomycin plus Ceftriaxone in Experimental Meningitis after Addition of Dexamethasone"],"prefix":"10.1128","volume":"53","author":[{"given":"U.","family":"Egermann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Stanga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ramin","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine, Klinik Sonnenhof, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stucki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gerber","sequence":"additional","affiliation":[{"name":"Clinic for Pneumology, Inselspital, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cottagnoud","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine, Spitalnetz Bern Ziegler, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Cottagnoud","sequence":"additional","affiliation":[{"name":"Clinic for Internal Medicine, Klinik Sonnenhof, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-11_Part_1-199812010-00004"},{"key":"e_1_3_2_3_2","first-page":"93","volume":"138","year":"2008","unstructured":"Cottagnoud, P. 2008. Daptomycin: a new treatment for insidious infections due to gram-positive pathogens. Swiss Med. Wkly.138:93-99.","journal-title":"Swiss Med. Wkly."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3928-3933.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.6.4.437"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1086\/514953","volume":"27","year":"1998","unstructured":"Doern, G. V., M. A. Pfaller, K. Kugler, J. Freeman, and R. N. Jones. 1998. Prevalence of antimicrobial resistance among respiratory tract isolates of Streptococcus pneumoniae in North America: 1997 results from the SENTRY antimicrobial surveillance program. Clin. Infect. Dis.27:764-770.","journal-title":"Clin. Infect. 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