{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:33:52Z","timestamp":1790314432716,"version":"4.1.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08AI114883"],"award-info":[{"award-number":["K08AI114883"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R03AI144636"],"award-info":[{"award-number":["R03AI144636"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI104895"],"award-info":[{"award-number":["R01AI104895"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI135522"],"award-info":[{"award-number":["R21AI135522"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["R00EY028222"],"award-info":[{"award-number":["R00EY028222"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            We report patient-to-patient transmission of\n            <jats:named-content content-type=\"genus-species\">Enterobacter hormaechei<\/jats:named-content>\n            isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the \u03a9-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibactam therapy, whereas the second patient had not received the agent and still became colonized with the KPC-40-producing strain.\n          <\/jats:p>","DOI":"10.1128\/aac.00955-19","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T13:09:42Z","timestamp":1563800982000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility"],"prefix":"10.1128","volume":"63","author":[{"given":"L. Silvia","family":"Munoz-Price","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison E.","family":"Reeme","sequence":"additional","affiliation":[{"name":"Department of Infection Prevention and Control, Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4111-048X","authenticated-orcid":false,"given":"Blake W.","family":"Buchan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta T.","family":"Mettus","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha M.","family":"Mustapha","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA"},{"name":"Center for Innovative Antimicrobial Therapy, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Van Tyne","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA"},{"name":"Center for Innovative Antimicrobial Therapy, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan K.","family":"Shields","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Pittsburgh, School of Medicine, 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