{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:12:11Z","timestamp":1762866731699},"reference-count":24,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,1]]},"abstract":"ABSTRACT<\/jats:title>To evaluate the antimicrobial susceptibility of Gram-negative bacilli that caused hospital-acquired and community-acquired intra-abdominal infections (IAIs) in China between 2012 and 2013, we determined the susceptibilities to 12 antimicrobials and the extended-spectrum \u03b2-lactamase (ESBL) statuses of 3,540 IAI isolates from seven geographic areas in China in a central laboratory using CLSI broth microdilution and interpretive standards. Most infections were caused byEscherichia coli<\/jats:named-content>(46.3%) andKlebsiella pneumoniae<\/jats:named-content>(19.7%). Rates of ESBL-producingE. coli<\/jats:named-content>(P<\/jats:italic>= 0.031),K. pneumoniae<\/jats:named-content>(P<\/jats:italic>= 0.017), andProteus mirabilis<\/jats:named-content>(P<\/jats:italic>= 0.004) were higher in hospital-acquired IAIs than in community-acquired IAIs. Susceptibilities of enterobacteriaceae to ertapenem, amikacin, piperacillin-tazobactam, and imipenem were 71.3% to 100%, 81.3% to 100%, 64.7% to 100%, and 83.1% to 100%, respectively, but imipenem was ineffective againstP. mirabilis<\/jats:named-content>(<20%). Although most ESBL-positive hospital-acquired isolates were resistant to third- and fourth-generation cephalosporins, the majority were susceptible to cefoxitin (47.9% to 83.9%). Susceptibilities of ESBL-positive isolates to ampicillin-sulbactam (<10%) were low, whereas susceptibilities to ciprofloxacin (0% to 54.6%) and levofloxacin (0% to 63.6%) varied substantially. The prevalences of cephalosporin-susceptibleE. coli<\/jats:named-content>andK. pneumoniae<\/jats:named-content>were higher in the northeastern and southern regions than in the central and eastern regions, reflecting the ESBL-positive rates in these areas, and were lowest in the Jiangsu-Zhejiang (Jiang-Zhe) area where the rates of carbapenem resistance were also highest. Ertapenem, amikacin, piperacillin-tazobactam, and imipenem are the most efficacious antibiotics for treating IAIs in China, especially those caused byE. coli<\/jats:named-content>orK. pneumoniae<\/jats:named-content>. Resistance to cephalosporins and carbapenems is more common in the Jiang-Zhe area than in other regions in China.<\/jats:p>","DOI":"10.1128\/aac.00956-15","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T12:34:21Z","timestamp":1445344461000},"page":"245-251","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Antimicrobial Susceptibilities of Aerobic and Facultative Gram-Negative Bacilli from Intra-abdominal Infections in Patients from Seven Regions in China in 2012 and 2013"],"prefix":"10.1128","volume":"60","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Peking Union Medical 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