{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:51:21Z","timestamp":1790077881439,"version":"4.0.1"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Three isolates of zygomycetes belonging to two different genera (\n Rhizopus oryzae<\/jats:italic>\n and\n Absidia corymbifera<\/jats:italic>\n ) were used to produce a systemic infection in neutropenic mice. On days \u22122 and \u22121 and at 2 h prior to infection, the mice received either posaconazole (POS) at doses ranging from 20 to 80 mg\/kg of body weight\/day or amphotericin B (AMB) at 1 mg\/kg\/day. Antifungal drug efficacy was assessed by determination of the prolongation of survival, determination of the percentage of infected organs (brain, lung, spleen, and kidney), and histological examination for the number of infection foci and their sizes in brain and kidney tissues. AMB significantly prolonged the survival of mice infected with all isolates. POS significantly prolonged the survival of mice infected with zygomycetes. Cultured organs from mice infected with\n R. oryzae<\/jats:italic>\n were all positive, while treated mice challenged with\n A. corymbifera<\/jats:italic>\n generally showed lower percentages of infected organs compared with the percentages for the controls. Zygomycete isolates established an active infection (the presence of hyphae) in the brains and the kidneys of all controls. In mice challenged with\n R. oryzae<\/jats:italic>\n , both antifungal drugs were effective at reducing the number and the size of infection foci in the kidneys. Only AMB reduced the numbers, but not the sizes, of infection foci in the brain. Finally, both drugs significantly reduced the numbers and the sizes of infection foci in both tissues of mice infected with\n A. corymbifera<\/jats:italic>\n . Our data suggest that prophylaxis with POS has some potential to prevent zygomycosis.\n <\/jats:p>","DOI":"10.1128\/aac.00969-06","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T18:32:51Z","timestamp":1166639571000},"page":"73-77","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Posaconazole Prophylaxis in Experimental Systemic Zygomycosis"],"prefix":"10.1128","volume":"51","author":[{"given":"Francesco","family":"Barchiesi","sequence":"first","affiliation":[{"name":"Istituto di Malattie Infettive e Medicina Pubblica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Spreghini","sequence":"additional","affiliation":[{"name":"Istituto di Malattie Infettive e Medicina Pubblica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Santinelli","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia Patologica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette W.","family":"Fothergill","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Pisa","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia Patologica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Giannini","sequence":"additional","affiliation":[{"name":"Centro Gestione Presidenza Medicina e Chirurgia, Universita\u0300 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas"},{"name":"Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Scalise","sequence":"additional","affiliation":[{"name":"Istituto di Malattie Infettive e Medicina Pubblica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-8-4-551"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362177885380181"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3647-3650.2003"},{"key":"e_1_3_1_5_2","first-page":"1192","year":"1989","unstructured":"Edwards, J., Jr. 1989. Zygomycosis, p. 1192-1199. In P. Hoeprich and M. Jordan (ed.), Infectious disease, 4th ed. J. B. Lippincott Co., Philadelphia, PA.","journal-title":"Infectious disease"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.721-727.2005"},{"key":"e_1_3_1_7_2","first-page":"241","year":"2003","unstructured":"Ibrahim, A. S., J. E. J. Edwards, and S. G. Filler. 2003. Zygomycosis, p. 241-251. In W. E. Dismukes, P. G. Pappas, and J. D. Sobel (ed.), Clinical mycology. Oxford University Press, New York, NY.","journal-title":"Clinical mycology"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/422729"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565110-00007"},{"key":"e_1_3_1_10_2","unstructured":"National Committee for Clinical Laboratory Standards. 2002. Reference method for broth dilution antifungal susceptibility testing of conidium-forming filamentous fungi. Approved standard M38-A. National Committee for Clinical Laboratory Standards Wayne PA."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.2.282"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/504328"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/432579"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.556-569.2005"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/500212"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.362-369.2006"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00969-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.00969-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:21:31Z","timestamp":1645471291000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.00969-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1128\/AAC.00969-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.00969-06","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"2006-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}