{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:04:55Z","timestamp":1780344295083,"version":"3.54.1"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n The increasing trend of \u03b2-lactam resistance among\n Enterobacteriaceae<\/jats:named-content>\n is a worldwide threat.\n Enterobacteriaceae<\/jats:named-content>\n isolates causing intra-abdominal infections (IAI) from the Study for Monitoring Antimicrobial Resistance Trends (SMART) collected in 2008 and 2009 from the Asia-Pacific region were investigated. Detection of extended-spectrum \u03b2-lactamases (ESBLs), AmpC \u03b2-lactamases, and carbapenemases was performed by multiplex PCR. A total of 699\n Enterobacteriaceae<\/jats:named-content>\n isolates with positive genotypic results, included\n Escherichia coli<\/jats:named-content>\n (\n n<\/jats:italic>\n = 443),\n Klebsiella pneumoniae<\/jats:named-content>\n (\n n<\/jats:italic>\n = 187),\n Enterobacter cloacae<\/jats:named-content>\n (\n n<\/jats:italic>\n = 45),\n Klebsiella oxytoca<\/jats:named-content>\n (\n n<\/jats:italic>\n = 9),\n Citrobacter freundii<\/jats:named-content>\n (\n n<\/jats:italic>\n = 5),\n Proteus mirabilis<\/jats:named-content>\n (\n n<\/jats:italic>\n = 3),\n Enterobacter aerogenes<\/jats:named-content>\n (\n n<\/jats:italic>\n = 2),\n Morganella morganii<\/jats:named-content>\n (\n n<\/jats:italic>\n = 2), and one each of\n Enterobacter asburiae<\/jats:named-content>\n ,\n Proteus vulgaris<\/jats:named-content>\n , and\n Providencia rettgeri<\/jats:named-content>\n were analyzed. Nearly 20% of these \u03b2-lactamase-producing\n Enterobacteriaceae<\/jats:named-content>\n isolates were from community-associated IAI. CTX-M (588 isolates, including 428 [72.8%] with CTX-M-15) was the most common ESBL, followed by SHV (\n n<\/jats:italic>\n = 59) and TEM (\n n<\/jats:italic>\n = 4). CMY (\n n<\/jats:italic>\n = 110, including 102 [92.7%] with CMY-2) was the most common AmpC \u03b2-lactamase, followed by DHA (\n n<\/jats:italic>\n = 46) and ACT\/MIR (\n n<\/jats:italic>\n = 40). NDM (\n n<\/jats:italic>\n = 65, including 62 [95.4%] with NDM-1) was the most common carbapenemase, followed by IMP (\n n<\/jats:italic>\n = 7) and OXA (\n n<\/jats:italic>\n = 7). Isolates from hospital-associated IAI had more complicated \u03b2-lactamase combinations than isolates from the community. Carbapenemases were all exclusively detected in\n Enterobacteriaceae<\/jats:named-content>\n isolates from India, except that IMP \u03b2-lactamases were also detected in Philippines and Australia. CTX-M \u03b2-lactamases were the predominant ESBLs produced by\n Enterobacteriaceae<\/jats:named-content>\n causing IAI in the Asia-Pacific region. Emergence of CTX-M-15-, CMY-2-, and NDM-1-producing\n Enterobacteriaceae<\/jats:named-content>\n isolates is of major concern and highlights the need for further surveillance in this area.\n <\/jats:p>","DOI":"10.1128\/aac.00971-12","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T01:48:44Z","timestamp":1366076924000},"page":"2981-2988","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":156,"title":["Distribution of Extended-Spectrum \u03b2-Lactamases, AmpC \u03b2-Lactamases, and Carbapenemases among Enterobacteriaceae Isolates Causing Intra-Abdominal Infections in the Asia-Pacific Region: Results of the Study for Monitoring Antimicrobial Resistance Trends (SMART)"],"prefix":"10.1128","volume":"57","author":[{"given":"Wang-Huei","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Badal","sequence":"additional","affiliation":[{"name":"International Health Management Associates, Schaumburg, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/500936"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70041-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.3018-3020.2005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00036-08"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2004.09.013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00565-10"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.657-686.2005"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00426-09"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.04.010"},{"key":"e_1_3_2_11_2","volume-title":"CLSI document M100-S20","author":"Clinical and Laboratory Standard Institute","year":"2010","unstructured":"Clinical and Laboratory Standard Institute. 2010. 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