{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:31:44Z","timestamp":1790469104200,"version":"4.1.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro<\/jats:italic>\n            susceptibilities of 46\n            <jats:italic>Leptospira<\/jats:italic>\n            isolates from rats to 14 antimicrobial agents were tested. All of the strains were found to be sensitive to ampicillin, cefotaxime, ciprofloxacin, norfloxacin, doxycycline, erythromycin, and streptomycin. In contrast, the tested isolates showed resistance to amphotericin B, 5-fluorouracil, fosfomycin, trimethoprim, sulfamethoxazole, neomycin, and vancomycin. These findings will help in selecting effective and ineffective antimicrobials for treatment of leptospirosis and for the development of new selective media, respectively.\n          <\/jats:p>","DOI":"10.1128\/aac.00973-10","type":"journal-article","created":{"date-parts":[[2010,9,21]],"date-time":"2010-09-21T04:51:28Z","timestamp":1285044688000},"page":"5403-5405","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["<i>In Vitro<\/i>\n            Sensitivity and Resistance of 46\n            <i>Leptospira<\/i>\n            Strains Isolated from Rats in the Philippines to 14 Antimicrobial Agents"],"prefix":"10.1128","volume":"54","author":[{"given":"Antara","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Y. 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M.","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina G.","family":"Gloriani","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, College of Public Health, University of the Philippines\u2014Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(86)90087-8"},{"key":"e_1_3_2_3_2","first-page":"1865","volume":"2","year":"2005","unstructured":"Adler, B., and S. Faine. 2005. Leptospira, p. 1865-1884. In S. P. Borriello, P. R. Murray, and G. Funke (ed.), Topley and Wilson's microbiology and microbial infections: Bacteriology, 10th ed., vol. 2. Hodder Arnold, London, United Kingdom.","journal-title":"Topley and Wilson's microbiology and microbial infections: Bacteriology"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.6.835"},{"key":"e_1_3_2_5_2","first-page":"371","volume":"58","year":"2009","unstructured":"Borgmann, S., T. Jakobiak, H. Gruber, H. Schr\u00f6der, and U. Sagel. 2009. Ciprofloxacin treatment of urinary infections results in increased resistance of urinary E. coli to ciprofloxacin and co-trimoxazole. Pol. J. Microbiol.58:371-373.","journal-title":"Pol. J. 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