{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:29:21Z","timestamp":1791041361190,"version":"4.1.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"F2G"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      We evaluated the\n                      <jats:italic>in vitro<\/jats:italic>\n                      activity of olorofim against\n                      <jats:italic>Coccidioides<\/jats:italic>\n                      species. Olorofim demonstrated potent\n                      <jats:italic>in vitro<\/jats:italic>\n                      activity against all isolates tested with a minimum inhibitory concentration (MIC) range \u22640.008\u20130.06 \u00b5g\/mL and geometric mean MIC of 0.010 \u00b5g\/mL. This activity was also maintained against isolates with elevated fluconazole MICs (\u226516 \u00b5g\/mL), including strains with MICs \u226532 \u00b5g\/mL (olorofim MIC range \u22640.008\u20130.06 \u00b5g\/mL and geometric mean MICs of \u22640.009 and \u22640.013 \u00b5g\/mL, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.00988-24","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T09:02:12Z","timestamp":1732179732000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Olorofim demonstrates\n                    <i>in vitro<\/i>\n                    activity against\n                    <i>Coccidioides<\/i>\n                    species, including isolates against which fluconazole has reduced activity"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-5122","authenticated-orcid":false,"given":"Nathan P.","family":"Wiederhold","sequence":"first","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]},{"name":"Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoja P.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Garcia","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California Davis","place":["Davis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-006-0065-4"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504203321607"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/496991"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-020-00431-2"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1029\/2019GH000209"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.27724"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.008"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/313747"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02634-16"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-007-9018-7"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608304113"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx177"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx065"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7050378"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00999-18"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx161"},{"key":"e_1_3_1_18_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi","author":"CLSI","year":"2017","unstructured":"CLSI. 2017. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. 3rd ed. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00593-15"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02258-17"},{"key":"e_1_3_1_21_2","volume-title":"Trends in medical mycology","author":"Maertens J","year":"2023","unstructured":"Maertens J, DonovaF, Thompson GR, Walsh S, Fitton L, Dane A, ZinziD, Harvey E, RexJ, Chen S. 2023. Olorofim treatment of mould IFD in patients with limited or no treatment options: results from a phase 2b open-label study, abstr 11th. In Trends in medical mycology."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00988-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.00988-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T09:04:43Z","timestamp":1738314283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.00988-24"}},"subtitle":[],"editor":[{"given":"Andreas H.","family":"Groll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,31]]}},"alternative-id":["10.1128\/aac.00988-24"],"URL":"https:\/\/doi.org\/10.1128\/aac.00988-24","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00988-24"}}