{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:16:33Z","timestamp":1761488193476},"reference-count":45,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Up-to-date information regarding the antibiotic susceptibility of\n            <jats:italic>Neisseria meningitidis<\/jats:italic>\n            strains from African countries is highly limited. Our aim was to comprehensively describe the antibiotic susceptibilities of a selection of\n            <jats:italic>N. meningitidis<\/jats:italic>\n            isolates recovered between 2000 and 2006 from 18 African countries, mainly those within the meningitis belt. Susceptibilities to 11 antibiotics were determined using Etest for 137\n            <jats:italic>N. meningitidis<\/jats:italic>\n            isolates (stringently selected from 693 available isolates). The isolates were also characterized by serogrouping, multilocus sequence typing, genosubtyping, and\n            <jats:italic>penA<\/jats:italic>\n            allele identification. All\n            <jats:italic>N. meningitidis<\/jats:italic>\n            isolates were susceptible to ceftriaxone, chloramphenicol, and ciprofloxacin. No isolate produced \u03b2-lactamase. Only three isolates (2%) displayed reduced susceptibility to penicillin G. The two isolates with the highest penicillin G MICs were the only isolates showing reduced susceptibility to ampicillin and cefuroxime. One of these isolates was also resistant to penicillin V. One percent of isolates displayed reduced susceptibility to rifampin, while 52% of the isolates were resistant to tetracycline, 74% were resistant to erythromycin, and 94% were resistant to sulfadiazine. The MICs of rifampin and tetracycline seemed to be associated with the serogroup of the isolates. In total, 18 sequence types (STs), 10 genosubtypes, and 8 different\n            <jats:italic>penA<\/jats:italic>\n            alleles were identified; the most common were ST-7, P1.20,9,35-1, and\n            <jats:italic>penA4<\/jats:italic>\n            , respectively. A high level of correlation was found between ST, genosubtype, and\n            <jats:italic>penA<\/jats:italic>\n            allele. In conclusion,\n            <jats:italic>N. meningitidis<\/jats:italic>\n            isolates from the African meningitis belt remain highly susceptible to the antibiotics used. Regarding \u03b2-lactam antibiotics, rare isolates showed a reduced susceptibility to penicillins, but the expanded-spectrum cephalosporins are not affected at present.\n          <\/jats:p>","DOI":"10.1128\/aac.00994-08","type":"journal-article","created":{"date-parts":[[2009,2,3]],"date-time":"2009-02-03T01:54:59Z","timestamp":1233626099000},"page":"1561-1566","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Antibiotic Susceptibility and Characteristics of\n            <i>Neisseria meningitidis<\/i>\n            Isolates from the African Meningitis Belt, 2000 to 2006: Phenotypic and Genotypic Perspectives"],"prefix":"10.1128","volume":"53","author":[{"given":"Sara Thulin","family":"Hedberg","sequence":"first","affiliation":[{"name":"National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, O\u0308rebro University Hospital, O\u0308rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Fredlund","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, O\u0308rebro University Hospital, O\u0308rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Nicolas","sequence":"additional","affiliation":[{"name":"French Forces Institute of Tropical Medicine (IMTSSA), WHO Collaborating Centre for Reference and Research on Meningococci, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique A.","family":"Caugant","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Reference and Research on Meningococci, Norwegian Institute of Public Health, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Olce\u0301n","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, O\u0308rebro University Hospital, O\u0308rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Unemo","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, O\u0308rebro University Hospital, O\u0308rebro, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh075"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/377739"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.3.285"},{"key":"e_1_3_2_5_2","first-page":"107","year":"2001","unstructured":"Arreaza, L., and J. 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