{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:47:05Z","timestamp":1790552825061,"version":"4.1.0"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>This study evaluated the pharmacological activity of PTX3, administered in combination with voriconazole, in a rat model of pulmonary aspergillosis. The data indicated additive therapeutic activities of these compounds, as demonstrated by the amelioration of respiratory function changes, reduction of lung fungal burden, and increased survival. Overall, we provide clear evidence that the combination of PTX3 with a suboptimal dose of voriconazole might represent a therapeutic option under those clinical conditions where the use of voriconazole alone is not warranted for efficacy and tolerability reasons.<\/jats:p>","DOI":"10.1128\/aac.01000-12","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T03:19:13Z","timestamp":1348543153000},"page":"6400-6402","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Effect of PTX3 and Voriconazole Combination in a Rat Model of Invasive Pulmonary Aspergillosis"],"prefix":"10.1128","volume":"56","author":[{"given":"Pietro","family":"Lo Giudice","sequence":"first","affiliation":[{"name":"sigma-tau Industrie Farmaceutiche Riunite S.p.A. 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Drug Resist."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00674-10"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01095-06"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01018-07"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1128\/AAC.42.9.2299","article-title":"Activity of voriconazole with neutrophils or monocytes against Aspergillus fumigatus: effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor","volume":"12","author":"Vora S","year":"1998","unstructured":"VoraS ChauhanS BrummerE StevensDA. 1998. Activity of voriconazole with neutrophils or monocytes against Aspergillus fumigatus: effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. Antimicrob. Agents Chemother. 12:2299\u20132303.","journal-title":"Antimicrob. 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