{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:45:48Z","timestamp":1773283548965,"version":"3.50.1"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Joint Program Initiative on Antimicrobial Resistance","award":["ANR-14-JAMR-0002"],"award-info":[{"award-number":["ANR-14-JAMR-0002"]}]},{"name":"European Community","award":["MAGIC-BULLET"],"award-info":[{"award-number":["MAGIC-BULLET"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Here, we characterized the first OXA-72-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:named-content>\n            isolate (designated MAL) recovered from a urine sample from a Serbian patient. Antimicrobial susceptibility testing, plasmid analysis, and whole-genome sequencing (WGS) were performed to fully characterize the resistome of the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n            MAL clinical isolate. The isolate was multidrug resistant and remained susceptible only to colistin and tigecycline. PCR analysis revealed the presence of the carbapenemase OXA-72, an OXA-40 variant. Extraction by the Kieser method revealed the presence of two plasmids, and one of these, a ca. 10-kb plasmid, harbored the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-72<\/jats:sub>\n            gene. WGS revealed 206 contigs corresponding to a genome of 3.9 Mbp in size with a G+C content of 38.8%. The isolate belonged to sequence type 492 and to worldwide clone II (WWCII). Naturally occurring \u03b2-lactamase-encoding genes (\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>ADC-25<\/jats:sub>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-66<\/jats:sub>\n            ) were also identified. Aminoglycoside resistance genes encoding one aminoglycoside adenyltransferase (\n            <jats:italic>aadA2<\/jats:italic>\n            ), three aminoglycoside phosphatases (\n            <jats:italic>strA<\/jats:italic>\n            ,\n            <jats:italic>strB<\/jats:italic>\n            ,\n            <jats:italic>aphA6<\/jats:italic>\n            ), and one 16S RNA methylase (\n            <jats:italic>armA<\/jats:italic>\n            ) conferring resistance to all aminoglycosides were identified. Resistance to fluoroquinolones was likely due to mutations in\n            <jats:italic>gyrA<\/jats:italic>\n            ,\n            <jats:italic>parC<\/jats:italic>\n            , and\n            <jats:italic>parE<\/jats:italic>\n            . Of note, the resistome matched perfectly with the antibiotic susceptibility testing results.\n          <\/jats:p>","DOI":"10.1128\/aac.01016-16","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T02:39:00Z","timestamp":1468895940000},"page":"5724-5730","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["First Occurrence of OXA-72-Producing Acinetobacter baumannii in Serbia"],"prefix":"10.1128","volume":"60","author":[{"given":"Laurent","family":"Dortet","sequence":"first","affiliation":[{"name":"Bacteriology-Hygiene Unit, Assistance Publique\/H\u00f4pitaux de Paris, Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"},{"name":"French National Reference Center for Antibiotic Resistance: Carbapenemase Producing Enterobacteriaceae, Le Kremlin-Bic\u00eatre, France"},{"name":"EA7391 (Structure, Dynamic, Function and Expression of Broad Spectrum \u03b2-Lactamases), Faculty 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Carbapenemase Producing Enterobacteriaceae, Le Kremlin-Bic\u00eatre, France"},{"name":"EA7391 (Structure, Dynamic, Function and Expression of Broad Spectrum \u03b2-Lactamases), Faculty of Medicine, University Paris-Sud, University Paris-Saclay, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9lia","family":"Escaut","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Assistance Publique\/H\u00f4pitaux de Paris, Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Vittecoq","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Assistance Publique\/H\u00f4pitaux de Paris, Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Girlich","sequence":"additional","affiliation":[{"name":"EA7391 (Structure, Dynamic, Function and 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