{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:01:07Z","timestamp":1698652867996},"reference-count":17,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The anticryptosporidial activity of Bobel-24 (2,4,6-triiodophenol) was studied for the first time, resulting in a reduction of the in vitro growth of\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            of up to 99.6%. In a SCID mouse model of chronic cryptosporidiosis, significant differences (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) in oocyst shedding were observed in animals treated with 125 mg\/kg\/day. These results merit further investigation of Bobel-24 as a chemotherapeutic option for cryptosporidiosis.\n          <\/jats:p>","DOI":"10.1128\/aac.01019-07","type":"journal-article","created":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T01:25:24Z","timestamp":1198718724000},"page":"1150-1152","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Bobel-24 Activity against\n            <i>Cryptosporidium parvum<\/i>\n            in Cell Culture and in a SCID Mouse Model"],"prefix":"10.1128","volume":"52","author":[{"given":"Cristina","family":"Rueda","sequence":"first","affiliation":[{"name":"Seccio\u0301n de Parasitologi\u0301a, Departamento de Bioqui\u0301mica, Biologi\u0301a Celular y Molecular, Facultad de Farmacia, Universidad San Pablo CEU, Urbanizacio\u0301n Montepri\u0301ncipe, Ctra. Boadilla del Monte km 5,300, 28668 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soledad","family":"Fenoy","sequence":"additional","affiliation":[{"name":"Seccio\u0301n de Parasitologi\u0301a, Departamento de Bioqui\u0301mica, Biologi\u0301a Celular y Molecular, Facultad de Farmacia, Universidad San Pablo CEU, Urbanizacio\u0301n Montepri\u0301ncipe, Ctra. Boadilla del Monte km 5,300, 28668 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Simo\u0301n","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologi\u0301a, Facultad de Farmacia, Universidad de Salamanca, Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"del Aguila","sequence":"additional","affiliation":[{"name":"Seccio\u0301n de Parasitologi\u0301a, Departamento de Bioqui\u0301mica, Biologi\u0301a Celular y Molecular, Facultad de Farmacia, Universidad San Pablo CEU, Urbanizacio\u0301n Montepri\u0301ncipe, Ctra. Boadilla del Monte km 5,300, 28668 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.390-400.2002"},{"key":"e_1_3_2_3_2","first-page":"23S","volume":"41","year":"1994","unstructured":"Arrowood, M. J., L. T. Xie, and M. R. Hurd. 1994. In vitro assays of maduramicin activity against Cryptosporidium parvum. J. Eukaryot. Microbiol.41:23S.","journal-title":"J. Eukaryot. Microbiol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70219-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1201-1208.1998"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(86)90368-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-4347(97)00645-2","volume":"708","year":"1998","unstructured":"Garc\u00eda-Capdevila, L., C. Lopez-Calull, S. Pompermayer, C. Arroyo, A. M. Molins-Pujol, and J. Bonal. 1998. High-performance liquid chromatography analysis of Bobel-24 in biological samples for pharmacokinetic, metabolic and tissue distribution studies. J. Chromatogr. B Biomed. Sci. Appl.708:169-175.","journal-title":"J. Chromatogr. B Biomed. Sci. 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