{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:43:03Z","timestamp":1777995783899,"version":"3.51.4"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:p>\n            High-confidence resistance mutations for new and repurposed anti-TB drugs, such as delamanid (DLM) and pretomanid (Pa), are rare and more data are needed in order to correctly interpret the results generated by genotypic drug susceptibility testing. In this study performed on clinical\n            <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n            complex isolates, we report that in the Swedish strain collection the\n            <jats:italic>ddn<\/jats:italic>\n            mutation Trp20Stop is found exclusively among DLM and Pa resistant (Pa MIC &gt;16\u2009mg\/L) isolates assigned to lineage 4.5.\n          <\/jats:p>","DOI":"10.1128\/aac.01026-22","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T14:04:11Z","timestamp":1669039451000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["The\n            <i>ddn<\/i>\n            Trp20Stop Mutation and Its Association with Lineage 4.5 and Resistance to Delamanid and Pretomanid in Mycobacterium tuberculosis"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-351X","authenticated-orcid":true,"given":"Mikael","family":"Mansj\u00f6","sequence":"first","affiliation":[{"name":"Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar","family":"Karlsson Lindsj\u00f6","sequence":"additional","affiliation":[{"name":"Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Gr\u00f6nfors Seeth","sequence":"additional","affiliation":[{"name":"Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Groenheit","sequence":"additional","affiliation":[{"name":"Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Werngren","sequence":"additional","affiliation":[{"name":"Public Health Agency of Sweden, Solna, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab505"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98862-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030466"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008287"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac070"},{"key":"e_1_3_3_7_2","volume-title":"Technical Report on critical concentrations for drug susceptibility testing of medicines used in the treatment of drug-resistant tuberculosis","year":"2018","unstructured":"Technical Report on critical concentrations for drug susceptibility testing of medicines used in the treatment of drug-resistant tuberculosis. 2018. World Health Organization, CC BY-NC-SA 3.0 IGO."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw044"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.775030"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01755-19"},{"key":"e_1_3_3_11_2","volume-title":"Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance","year":"2021","unstructured":"Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. 2021. Geneva: World Health Organization. Licence: CC BY-NC-SA 3.0 IGO."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27616-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00726-5"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01026-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01026-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T14:07:56Z","timestamp":1671545276000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01026-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12,20]]}},"alternative-id":["10.1128\/aac.01026-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.01026-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"assertion":[{"value":"2022-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01026-22"}}