{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:23:42Z","timestamp":1788715422413,"version":"build-2803163510"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX000984"],"award-info":[{"award-number":["1I01BX000984"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01BX004677-01A1"],"award-info":[{"award-number":["1I01BX004677-01A1"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2023,1,24]]},"abstract":"<jats:p>\n            Limited therapeutic options dictate the need for new classes of antimicrobials active against carbapenem-resistant\n            <jats:named-content content-type=\"genus-species\">Acinetobacter baumannii<\/jats:named-content>\n            . Presented data confirm and extend penicillin binding protein 7\/8 (PBP 7\/8) as a high-value target in the CR\n            <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n            strain HUMC1.\n          <\/jats:p>","DOI":"10.1128\/aac.01033-22","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T14:00:35Z","timestamp":1670421635000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Penicillin Binding Protein 7\/8 Is a Potential Drug Target in Carbapenem-Resistant Acinetobacter baumannii"],"prefix":"10.1128","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4566-7442","authenticated-orcid":true,"given":"Thomas A.","family":"Russo","sequence":"first","affiliation":[{"name":"Veterans Administration Western New York Healthcare System, Buffalo, New York, USA"},{"name":"Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA"},{"name":"Department of Microbiology and Immunology, University at Buffalo, State University of New York, Buffalo, New York, USA"},{"name":"The Witebsky Center for Microbial Pathogenesis, University at Buffalo, State University of New York, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Carlino-MacDonald","sequence":"additional","affiliation":[{"name":"Veterans Administration Western New York Healthcare System, Buffalo, New York, USA"},{"name":"Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra L.","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Veterans Administration Western New York Healthcare System, Buffalo, New York, USA"},{"name":"Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor J.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grishma","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parijat","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hutson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-0689","authenticated-orcid":true,"given":"Felise G.","family":"Adams","sequence":"additional","affiliation":[{"name":"Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoge","family":"Zang","sequence":"additional","affiliation":[{"name":"Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-7973","authenticated-orcid":true,"given":"Alice","family":"Ascari","sequence":"additional","affiliation":[{"name":"Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia"},{"name":"School of Biological Sciences, Department of Molecular and Biomedical Science, Research Centre for Infectious Diseases, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-8977","authenticated-orcid":true,"given":"Bart A.","family":"Eijkelkamp","sequence":"additional","affiliation":[{"name":"Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab696"},{"key":"e_1_3_3_4_2","volume-title":"COVID-19: U.S. impact on antimicrobial resistance, special report 2022.","author":"Centers for Disease Control","year":"2022","unstructured":"Centers for Disease Control. 2022. COVID-19: U.S. impact on antimicrobial resistance, special report 2022. CDC, Atlanta, GA."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics7040096"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.715213"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0038-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18082"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_3_3_11_2","unstructured":"Centers for Disease Control. 2013. Antibiotic resistance threats in the United States 2013. https:\/\/www.cdc.gov\/drugresistance\/pdf\/ar-threats-2013-508.pdf."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz830"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02759-21"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00054-22"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70318-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq179"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70293-1"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00459-11"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.13.3981-3993.1999"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.8.2074-2079.1995"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.00597.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.1.256-259.1994"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01001-22"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.11.4912-4915.1987"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/005199-0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00476-06"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.04.006"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2006.00024.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/596317"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01660-15"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700877"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg097"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000238887"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4572"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00113-12"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2014.04.019"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2009.022"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.111821"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.5.3572"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108129"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02390-17"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.09.010"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl403"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05150-14"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.5b00097"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18301-2"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00651-10"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006512"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.06.005"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6985"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.10.016"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00591-17"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01313-14"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.595798"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00705-16"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00188-15"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00082-16"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.4.1263-1269.1995"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2000.00971.x"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-021-01179-3"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00192"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2022.183871"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.3791\/2437"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.112797"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00093-17"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01033-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01033-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T14:03:46Z","timestamp":1674569026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01033-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,24]]}},"alternative-id":["10.1128\/aac.01033-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.01033-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]},"assertion":[{"value":"2022-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01033-22"}}