{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:54:37Z","timestamp":1790801677862,"version":"4.1.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n            Emergence of resistance to polymyxins in\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            is mainly due to mutations in two-component systems that promote the addition of 4-amino-4-deoxy-\n            <jats:sc>l<\/jats:sc>\n            -arabinose to the lipopolysaccharide (LPS) through upregulation of operon\n            <jats:italic>arnBCADTEF-ugd<\/jats:italic>\n            (\n            <jats:italic>arn<\/jats:italic>\n            ) expression. Here, we demonstrate that mutations occurring in different domains of histidine kinase PmrB or in response regulator PmrA result in coresistance to aminoglycosides and colistin.\n          <\/jats:p>","DOI":"10.1128\/aac.01044-19","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T12:30:40Z","timestamp":1565008240000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Production of Norspermidine Contributes to Aminoglycoside Resistance in\n            <i>pmrAB<\/i>\n            Mutants of Pseudomonas aeruginosa"],"prefix":"10.1128","volume":"63","author":[{"given":"Arnaud","family":"Bolard","sequence":"first","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Besan\u00e7on, Besan\u00e7on, France"},{"name":"UMR6249 Chrono-environnement, Facult\u00e9 de M\u00e9decine-Pharmacie, 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