{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:27:22Z","timestamp":1791419242318,"version":"4.3.3"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI097142"],"award-info":[{"award-number":["1R01AI097142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5K12HD068373"],"award-info":[{"award-number":["5K12HD068373"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["HHS272201000018I"],"award-info":[{"award-number":["HHS272201000018I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of\n in vitro<\/jats:italic>\n activity and\n in vivo<\/jats:italic>\n activity of AR-12, a celecoxib derivative which has been tested in a phase I clinical trial as an anticancer agent. AR-12 inhibits fungal acetyl coenzyme A (acetyl-CoA) synthetase\n in vitro<\/jats:italic>\n and is fungicidal at concentrations similar to those achieved in human plasma. AR-12 has a broad spectrum of activity, including activity against yeasts (e.g.,\n Candida albicans<\/jats:named-content>\n , non-\n albicans Candida<\/jats:named-content>\n spp.,\n Cryptococcus neoformans<\/jats:named-content>\n ), molds (e.g.,\n Fusarium<\/jats:named-content>\n ,\n Mucor<\/jats:italic>\n ), and dimorphic fungi (\n Blastomyces<\/jats:named-content>\n ,\n Histoplasma<\/jats:named-content>\n , and\n Coccidioides<\/jats:named-content>\n ) with MICs of 2 to 4 \u03bcg\/ml. AR-12 is also active against azole- and echinocandin-resistant\n Candida<\/jats:named-content>\n isolates, and subinhibitory AR-12 concentrations increase the susceptibility of fluconazole- and echinocandin-resistant\n Candida<\/jats:named-content>\n isolates. Finally, AR-12 also increases the activity of fluconazole in a murine model of cryptococcosis. Taken together, these data indicate that AR-12 represents a promising class of small molecules with broad-spectrum antifungal activity.\n <\/jats:p>","DOI":"10.1128\/aac.01061-16","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T01:59:47Z","timestamp":1474336787000},"page":"7115-7127","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":83,"title":["The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity\n In Vitro<\/i>\n and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis"],"prefix":"10.1128","volume":"60","author":[{"given":"Kristy","family":"Koselny","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"DiDone","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin P.","family":"Halterman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette W.","family":"Fothergill","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, 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