{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:16:37Z","timestamp":1789514197088,"version":"build-2803163510"},"reference-count":67,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n            Paracoccidioidomycosis (PCM), caused by\n            <jats:italic>Paracoccidioides<\/jats:italic>\n            , is a systemic mycosis with granulomatous character and a restricted therapeutic arsenal. The aim of this work was to search for new alternatives to treat largely neglected tropical mycosis, such as PCM.\n          <\/jats:p>","DOI":"10.1128\/aac.01097-18","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T10:00:00Z","timestamp":1539770400000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Promising New Antifungal Treatment Targeting Chorismate Synthase from\n            <i>Paracoccidioides brasiliensis<\/i>"],"prefix":"10.1128","volume":"63","author":[{"given":"Franciele Abigail Vilugron","family":"Rodrigues-Vendramini","sequence":"first","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Maring\u00e1, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cidnei","family":"Marschalk","sequence":"additional","affiliation":[{"name":"Department of Technology, Universidade Estadual de Maring\u00e1, Umuarama, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Toplak","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry, Graz University of Technology, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Macheroux","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry, Graz University of Technology, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia de Souza","family":"Bonfim-Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Maring\u00e1, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terezinha Inez Estivalet","family":"Svidzinski","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Maring\u00e1, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio Augusto Vicente","family":"Seixas","sequence":"additional","affiliation":[{"name":"Department of Technology, Universidade Estadual de Maring\u00e1, Umuarama, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Seki","family":"Kioshima","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maring\u00e1, Maring\u00e1, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"138","article-title":"Epidemiology, clinical, and therapeutic aspects of paracoccidioidomycosis","volume":"1","author":"da Costa MM","year":"2014","unstructured":"da Costa MM, da Silva SHM. 2014. Epidemiology, clinical, and therapeutic aspects of paracoccidioidomycosis. Trop Mycol Curr Trop Med Rep 1:138\u2013144.","journal-title":"Trop Mycol Curr Trop Med Rep"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.13.68"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.11-0084"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2002000500037"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3010001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0230-2017"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30306-7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep40406"},{"key":"e_1_3_3_10_2","first-page":"12","article-title":"Comparative genomics allowed the identification of drug targets against human fungal pathogens","volume":"27","author":"Abadio AK","year":"2011","unstructured":"Abadio AK, Kioshima ES, Teixeira MM, Martins NF, Maigret B, Felipe MS. 2011. Comparative genomics allowed the identification of drug targets against human fungal pathogens. BMC Genomics 27:12\u201375.","journal-title":"BMC Genomics"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/10409239009090615"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1518"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.50.1.473"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2174\/138945007780058924"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1376"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004250050489"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310380200"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/12.2.85"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3975"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl065"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2011.07.011"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02231-12"},{"key":"e_1_3_3_23_2","first-page":"CD010481","article-title":"Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function","volume":"23","author":"Aguirre JPB","year":"2015","unstructured":"Aguirre JPB, Hamid AMR. 2015. Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function. Cochrane Database Syst Rev 23:CD010481.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myt012"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.40.4.411.417"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019703"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-017-0152-6"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2009.06.003"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142926"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00165-17"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-9-30"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku427"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093960"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/522973"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx080"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1086\/377538"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2010.09.005"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.07.027"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx087"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002345"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-515-2_5"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top17"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp302"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2003.11.005"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.12.072"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0506s15"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20065"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci3001277"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21816"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.81"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb25530a"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/cen-v087n005.p032"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm051197e"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1072"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1049"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(90)90141-K"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100867200"},{"key":"e_1_3_3_60_2","first-page":"177","article-title":"The polysaccharidic antigen from Paracoccidioides brasiliensis. Study of the time of cultivation necessary for the preparation of the antigen","volume":"11","author":"Fava-Netto C","year":"1969","unstructured":"Fava-Netto C, Vegas VS, Sciannam\u00e9a IM, Guarnieri DB. 1969. The polysaccharidic antigen from Paracoccidioides brasiliensis. Study of the time of cultivation necessary for the preparation of the antigen. Rev Inst Med Trop 11:177\u2013181.","journal-title":"Rev Inst Med Trop"},{"key":"e_1_3_3_61_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeast","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of yeast, 3rd ed. Approved standard CLSI M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02231-12"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.06.008"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/287693"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.10.044"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.10.019"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002512"},{"key":"e_1_3_3_68_2","unstructured":"Minist\u00e9rio da Ci\u00eancia Tecnologia e Inova\u00e7\u00e3o Conselho Nacional de Controle de Experimenta\u00e7\u00e3o Animal (CONCEA) Brazil. 2016. Guia brasileiro de produ\u00e7\u00e3o manuten\u00e7\u00e3o ou utiliza\u00e7\u00e3o de animais em atividades de ensino ou pesquisa cient\u00edfica. https:\/\/www.mctic.gov.br\/mctic\/export\/sites\/institucional\/legislacao\/Arquivos\/Anexo_Res_Normativa_Concea_33_2016.pdf."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01097-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01097-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:22:26Z","timestamp":1645478546000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01097-18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1128\/AAC.01097-18"],"URL":"https:\/\/doi.org\/10.1128\/aac.01097-18","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2018-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01097-18"}}