{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:27:27Z","timestamp":1785475647649,"version":"3.56.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have\n            <jats:italic>in vitro<\/jats:italic>\n            activity against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium tuberculosis<\/jats:named-content>\n            ; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patients in sub-Saharan Africa. Thirty-eight of 40\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Mycobacterium tuberculosis<\/jats:named-content>\n            isolates (95%) from pretreatment sputum samples from Ugandan adults with pulmonary TB, including HIV-infected patients taking trimethoprim-sulfamethoxazole prophylaxis, were susceptible with MICs of \u226438.4 \u03bcg\/ml.\n          <\/jats:p>","DOI":"10.1128\/aac.01101-15","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T02:24:44Z","timestamp":1436840684000},"page":"5844-5846","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Sulfamethoxazole Susceptibility of Mycobacterium tuberculosis Isolates from HIV-Infected Ugandan Adults with Tuberculosis Taking Trimethoprim-Sulfamethoxazole Prophylaxis"],"prefix":"10.1128","volume":"59","author":[{"given":"Sam","family":"Ogwang","sequence":"first","affiliation":[{"name":"Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda"},{"name":"Joint Clinical Research Centre, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn E.","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Okware","sequence":"additional","affiliation":[{"name":"Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Nsereko","sequence":"additional","affiliation":[{"name":"Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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Pediatrics 25:1035\u20131042.","journal-title":"Pediatrics"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01658-08"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00832-12"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks306"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00029-10"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr501"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00114812"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2013.07.011"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fgene.2013.00061","article-title":"The household contact study design for genetic epidemiological studies of infectious diseases","volume":"4","author":"Stein CM","year":"2013","unstructured":"Stein CM, Hall NB, Malone LL, Mupere E. 2013. The household contact study design for genetic epidemiological studies of infectious diseases. Front Genet 4:61.","journal-title":"Front Genet"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg227"},{"key":"e_1_3_2_16_2","volume-title":"Global tuberculosis report 2014","author":"World Health Organization","year":"2014","unstructured":"World Health Organization. 2014. Global tuberculosis report 2014. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_17_2","volume-title":"Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes\u2014","author":"Clinical and Laboratory Standards Institute","year":"2011","unstructured":"Clinical and Laboratory Standards Institute. 2011. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes\u20142nd ed. CLSI document M24-A2. 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